Safety

271 of 1605 entries · showing the first 80 — narrow the search to see the rest · Clear

• 7-Keto-DHEA: side effects, safety & interactions

  Generally tolerated short-term; long-term data limited.

  Safety · revised Jul 10, 2026

  DEvidence grade D
• Acetyl-L-Carnitine (ALCAR): side effects, safety & interactions

  Generally safe; can cause GI upset, and, like carnitine, may raise TMAO. Mildly stimulating for some — take earlier in t

  Safety · revised Jul 10, 2026

  BEvidence grade B
• Activated Charcoal: side effects, safety & interactions

  Binds oral drugs (including contraceptives) — separate by hours; not for routine use.

  Safety · revised Jul 10, 2026

  CEvidence grade C
• Agmatine: side effects, safety & interactions

  Limited human safety data; generally tolerated short-term.

  Safety · revised Jul 10, 2026

  DEvidence grade D
• AHCC: side effects, safety & interactions

  Generally well tolerated; mild GI effects. As an immune stimulant, caution with immunosuppressants/autoimmunity.

  Safety · revised Jul 10, 2026

  CEvidence grade C
• Akkermansia muciniphila: side effects, safety & interactions

  Well tolerated in the trial; long-term safety of a novel single-strain probiotic is not established.

  Safety · revised Jul 10, 2026

  CEvidence grade C
• Algae Omega-3: side effects, safety & interactions

  Safe and sustainable; mild antiplatelet effect at high doses.

  Safety · revised Jul 10, 2026

  BEvidence grade B
• Aloe Vera: side effects, safety & interactions

  Topical is safe; oral aloe latex is a stimulant laxative with real risks — avoid it.

  Safety · revised Jul 10, 2026

  CEvidence grade C
• Alpha-GPC: side effects, safety & interactions

  Generally tolerated; the observational stroke-risk signal is unresolved and worth noting for high chronic use.

  Safety · revised Jul 10, 2026

  CEvidence grade C
• Alpha-Lipoic Acid: side effects, safety & interactions

  Generally safe; can lower glucose (watch for lows with diabetes meds) and rarely triggers an insulin-autoimmune reaction

  Safety · revised Jul 10, 2026

  BEvidence grade B
• American Ginseng: side effects, safety & interactions

  Generally safe; additive glucose lowering; may reduce warfarin effect.

  Safety · revised Jul 10, 2026

  CEvidence grade C
• Andrographis: side effects, safety & interactions

  GI upset, allergy; possible additive immune/anticoagulant effects; avoid in pregnancy.

  Safety · revised Jul 10, 2026

  BEvidence grade B
• Aniracetam: side effects, safety & interactions

  Generally tolerated; take with fat. Legally grey as a supplement.

  Safety · revised Jul 10, 2026

  DEvidence grade D
• Apigenin: side effects, safety & interactions

  Benign at these doses; theoretical mild CYP interactions at high intakes.

  Safety · revised Jul 10, 2026

  CEvidence grade C
• Apple Cider Vinegar: side effects, safety & interactions

  Dilute it — undiluted vinegar damages enamel and the esophagus; additive glucose lowering; caution with low potassium.

  Safety · revised Jul 10, 2026

  CEvidence grade C
• Artichoke Leaf Extract: side effects, safety & interactions

  Generally safe; caution with bile-duct obstruction.

  Safety · revised Jul 10, 2026

  CEvidence grade C
• Astaxanthin: side effects, safety & interactions

  Safe; harmless slight skin-tone change at high doses.

  Safety · revised Jul 10, 2026

  CEvidence grade C
• Astragalus: side effects, safety & interactions

  Generally safe; immune-stimulating, so caution with immunosuppressants/autoimmunity.

  Safety · revised Jul 10, 2026

  CEvidence grade C
• ATP (Peak ATP): side effects, safety & interactions

  Appears safe.

  Safety · revised Jul 10, 2026

  DEvidence grade D
• Bacopa Monnieri: side effects, safety & interactions

  Generally safe; GI upset (cramping, loose stools) is common, easing when taken with food. Mild sedative and thyroid-horm

  Safety · revised Jul 10, 2026

  BEvidence grade B
• Banaba (Corosolic Acid): side effects, safety & interactions

  Generally safe; additive glucose lowering.

  Safety · revised Jul 10, 2026

  CEvidence grade C
• BCAAs: side effects, safety & interactions

  Safe; largely a waste of money if protein intake is adequate.

  Safety · revised Jul 10, 2026

  CEvidence grade C
• Bee Propolis: side effects, safety & interactions

  Generally safe, but a notable allergen — people allergic to bee products can react. Patch-test topicals.

  Safety · revised Jul 10, 2026

  CEvidence grade C
• Beetroot / Dietary Nitrate: side effects, safety & interactions

  Safe; harmless pink urine/stool. Additive blood-pressure lowering with antihypertensives.

  Safety · revised Jul 10, 2026

  BEvidence grade B
• Berberine: side effects, safety & interactions

  GI upset is common. Treat it as a drug: additive hypoglycemia with diabetes medication, CYP-mediated interactions, and a

  Safety · revised Jul 10, 2026

  BEvidence grade B
• Bergamot (Citrus Bergamia): side effects, safety & interactions

  Generally safe; theoretical additive effect with statins.

  Safety · revised Jul 10, 2026

  CEvidence grade C
• Beta-Alanine: side effects, safety & interactions

  Safe; the only common effect is transient skin tingling. Splitting doses or using sustained-release forms minimizes it.

  Safety · revised Jul 10, 2026

  AEvidence grade A
• Beta-Carotene: side effects, safety & interactions

  Food amounts are safe (excess just yellows skin). High-dose supplements are contraindicated in smokers and asbestos-expo

  Safety · revised Jul 10, 2026

  CEvidence grade C
• Beta-Glucans: side effects, safety & interactions

  Very safe; gas/bloating with the soluble-fiber form.

  Safety · revised Jul 10, 2026

  BEvidence grade B
• Beta-Sitosterol: side effects, safety & interactions

  Generally safe; mild GI effects.

  Safety · revised Jul 10, 2026

  BEvidence grade B
• Betaine (TMG): side effects, safety & interactions

  Well tolerated; can raise LDL/triglycerides slightly at high doses.

  Safety · revised Jul 10, 2026

  CEvidence grade C
• Betaine HCl: side effects, safety & interactions

  Can worsen reflux/ulcers and irritate the stomach; never combine with acid-reducing drugs; don't use with NSAIDs.

  Safety · revised Jul 10, 2026

  DEvidence grade D
• Bilberry: side effects, safety & interactions

  Very safe as a food/extract; mild antiplatelet effect at high doses.

  Safety · revised Jul 10, 2026

  CEvidence grade C
• Biotin (B7): side effects, safety & interactions

  Safe, but the lab-test interference is a real clinical hazard — disclose supplementation before testing.

  Safety · revised Jul 10, 2026

  CEvidence grade C
• Bitter Melon: side effects, safety & interactions

  Hypoglycemia risk; avoid in pregnancy (traditional abortifacient).

  Safety · revised Jul 10, 2026

  CEvidence grade C
• Black Cohosh: side effects, safety & interactions

  Rare hepatotoxicity reports — stop if any liver symptoms; avoid in liver disease.

  Safety · revised Jul 10, 2026

  CEvidence grade C
• Black Seed Oil (Nigella sativa): side effects, safety & interactions

  Generally well tolerated; can add to glucose- and blood-pressure-lowering medications, and may affect drug metabolism at

  Safety · revised Jul 10, 2026

  CEvidence grade C
• Boron: side effects, safety & interactions

  Safe at these doses; toxicity requires far higher intakes.

  Safety · revised Jul 10, 2026

  CEvidence grade C
• Boswellia: side effects, safety & interactions

  Well tolerated; occasional GI upset.

  Safety · revised Jul 10, 2026

  BEvidence grade B
• Bovine Colostrum: side effects, safety & interactions

  Generally safe; dairy-allergy caution.

  Safety · revised Jul 10, 2026

  CEvidence grade C
• BPC-157: side effects, safety & interactions

  No human safety data; sourced from unregulated suppliers with purity/contamination risk. Not an approved drug.

  Safety · revised Jul 10, 2026

  DEvidence grade D
• Bromelain: side effects, safety & interactions

  Generally safe; mild antiplatelet action; pineapple-allergy caution.

  Safety · revised Jul 10, 2026

  CEvidence grade C
• Butterbur: side effects, safety & interactions

  PA-containing products are hepatotoxic and carcinogenic — use only PA-free certified extracts.

  Safety · revised Jul 10, 2026

  BEvidence grade B
• Butyrate: side effects, safety & interactions

  Generally safe; oral forms can smell/taste unpleasant.

  Safety · revised Jul 10, 2026

  CEvidence grade C
• Caffeine: side effects, safety & interactions

  Safe for most in moderation; excess causes anxiety, palpitations, and insomnia. Dependence and withdrawal (headache, fat

  Safety · revised Jul 10, 2026

  AEvidence grade A
• Calcium AKG: side effects, safety & interactions

  Appears safe short-term; long-term unknown.

  Safety · revised Jul 10, 2026

  DEvidence grade D
• Calcium D-Glucarate: side effects, safety & interactions

  Appears safe; may accelerate clearance of glucuronidated drugs.

  Safety · revised Jul 10, 2026

  DEvidence grade D
• Calcium: side effects, safety & interactions

  Constipation and, at high supplemental doses, kidney-stone and possibly cardiovascular concerns. Prefer dietary calcium

  Safety · revised Jul 10, 2026

  BEvidence grade B
• Capsaicin / Capsimax: side effects, safety & interactions

  GI burning at high oral doses; topical can sting. Beadlet forms reduce oral discomfort.

  Safety · revised Jul 10, 2026

  CEvidence grade C
• Carnosine: side effects, safety & interactions

  Well tolerated.

  Safety · revised Jul 10, 2026

  CEvidence grade C
• Casein Protein: side effects, safety & interactions

  Very safe; contains lactose.

  Safety · revised Jul 10, 2026

  BEvidence grade B
• Cat's Claw: side effects, safety & interactions

  Generally tolerated; caution with immunosuppressants and autoimmune conditions.

  Safety · revised Jul 10, 2026

  CEvidence grade C
• CBD (Cannabidiol): side effects, safety & interactions

  Generally well tolerated (fatigue, diarrhea, appetite changes); high doses can raise liver enzymes. Clinically important

  Safety · revised Jul 10, 2026

  BEvidence grade B
• Centrophenoxine: side effects, safety & interactions

  Generally tolerated.

  Safety · revised Jul 10, 2026

  DEvidence grade D
• Chaga: side effects, safety & interactions

  Oxalate load — kidney-stone/injury risk; caution with anticoagulants and diabetes drugs.

  Safety · revised Jul 10, 2026

  DEvidence grade D
• Chlorella: side effects, safety & interactions

  Generally safe; GI upset early; vitamin-K content matters for warfarin; possible photosensitivity.

  Safety · revised Jul 10, 2026

  CEvidence grade C
• Choline: side effects, safety & interactions

  High doses cause fishy odor and GI effects; very high intakes may raise TMAO.

  Safety · revised Jul 10, 2026

  BEvidence grade B
• Chondroitin: side effects, safety & interactions

  Well tolerated.

  Safety · revised Jul 10, 2026

  CEvidence grade C
• Chromium: side effects, safety & interactions

  Generally safe at supplemental doses; the issue is lack of benefit, not harm.

  Safety · revised Jul 10, 2026

  DEvidence grade D
• Cinnamon: side effects, safety & interactions

  High-dose cassia coumarin can stress the liver; additive glucose lowering with diabetes drugs.

  Safety · revised Jul 10, 2026

  CEvidence grade C
• Cissus Quadrangularis: side effects, safety & interactions

  Generally tolerated; limited data.

  Safety · revised Jul 10, 2026

  CEvidence grade C
• Cistanche: side effects, safety & interactions

  Generally tolerated; limited safety data.

  Safety · revised Jul 10, 2026

  DEvidence grade D
• Citicoline (CDP-Choline): side effects, safety & interactions

  Well tolerated; occasional headache or GI upset.

  Safety · revised Jul 10, 2026

  CEvidence grade C
• CLA (Conjugated Linoleic Acid): side effects, safety & interactions

  High-dose synthetic CLA may adversely affect metabolic markers.

  Safety · revised Jul 10, 2026

  DEvidence grade D
• Cocoa Flavanols: side effects, safety & interactions

  Safe; watch caffeine/theobromine and the sugar in chocolate.

  Safety · revised Jul 10, 2026

  BEvidence grade B
• Coenzyme Q10: side effects, safety & interactions

  Very safe; mild GI upset. May slightly reduce warfarin's effect (monitor INR).

  Safety · revised Jul 10, 2026

  BEvidence grade B
• Collagen Peptides: side effects, safety & interactions

  Very safe; it is food-grade protein. It is not a complete protein, so it doesn't count toward muscle-building protein ta

  Safety · revised Jul 10, 2026

  BEvidence grade B
• Copper: side effects, safety & interactions

  Excess causes GI symptoms and, chronically, liver and neurological harm. Balance with zinc rather than dosing high.

  Safety · revised Jul 10, 2026

  CEvidence grade C
• Cordyceps: side effects, safety & interactions

  Generally safe.

  Safety · revised Jul 10, 2026

  DEvidence grade D
• Cranberry: side effects, safety & interactions

  Safe; juice carries sugar; theoretical mild warfarin interaction at high intake.

  Safety · revised Jul 10, 2026

  BEvidence grade B
• Curcumin (Turmeric): side effects, safety & interactions

  Well tolerated; high doses can cause GI upset. It has mild antiplatelet action (additive with anticoagulants) and, via p

  Safety · revised Jul 10, 2026

  BEvidence grade B
• D-Chiro-Inositol: side effects, safety & interactions

  Generally safe; ratio matters more than dose.

  Safety · revised Jul 10, 2026

  BEvidence grade B
• D-Mannose: side effects, safety & interactions

  Well tolerated; caution in diabetes (it is a sugar, though minimally metabolized).

  Safety · revised Jul 10, 2026

  CEvidence grade C
• Deer Antler Velvet: side effects, safety & interactions

  Generally tolerated; the concern is anti-doping status (IGF-1) more than toxicity.

  Safety · revised Jul 10, 2026

  DEvidence grade D
• DGL (Licorice): side effects, safety & interactions

  DGL is safe; regular licorice is not (hypertension, hypokalemia) — use the DGL form.

  Safety · revised Jul 10, 2026

  CEvidence grade C
• DHEA: side effects, safety & interactions

  Hormonal side effects (acne, hair changes, and hormone-sensitive-cancer concerns); it is not a benign supplement. Banned

  Safety · revised Jul 10, 2026

  CEvidence grade C
• Digestive Enzymes: side effects, safety & interactions

  Generally safe; true insufficiency needs medical management, not OTC blends.

  Safety · revised Jul 10, 2026

  CEvidence grade C
• DIM (Diindolylmethane): side effects, safety & interactions

  Generally tolerated; can alter drug metabolism and hormone levels.

  Safety · revised Jul 10, 2026

  CEvidence grade C
• Diosmin / Hesperidin: side effects, safety & interactions

  Generally safe; mild GI effects.

  Safety · revised Jul 10, 2026

  BEvidence grade B
• DMAE: side effects, safety & interactions

  Generally tolerated; avoid in pregnancy given developmental concerns.

  Safety · revised Jul 10, 2026

  DEvidence grade D