PrometheusGeneral

Evidence library · 930 graded entries · 1605 pages in all

What the evidence says, and how sure it is.

Prometheus General is an open library of graded evidence on supplements, medicines, conditions, training and sleep — every outcome graded A to D, every uncertainty said — with tools to compare it and a workbench to investigate it. Reading needs no account.

TryCreatine, Magnesium, Vitamin D, Melatonin, Ashwagandha, Caffeine, Berberine, Zinc

Evidence matrix

Conditions against interventions

103 graded links between 57 conditions and 69 interventions, each with its direction.

Compare

Two entries, side by side

Their outcomes, grades, conditions and cautions in one table — and where they meet.

Notebook

Watch an investigation reason

A sample investigation: competing explanations, the checks that test them, the next experiment. Run on invented example data.

Start with these

The library's hand-written flagship entries.

  • Creatine

    The most-studied performance supplement in existence — and it quietly helps brains too.

    5 graded outcomes · 4 conditions · revised Jun 20, 2026

    Evidence grade A
  • Omega-3 (EPA/DHA)

    Triglyceride-lowering is bankable; everything else scales with your baseline fish intake.

    4 graded outcomes · 4 conditions · revised Jun 8, 2026

    Evidence grade A
  • Sleep architecture

    The recovery system everything else compounds on — deep and REM timing matter more than raw hours.

    4 graded outcomes · 4 conditions · revised Jun 28, 2026

    Evidence grade A
  • Hypertension

    The silent driver of cardiovascular risk — and one of the most lifestyle-responsive conditions there is.

    5 graded outcomes · revised Jul 18, 2026

    Evidence grade A
  • Zone 2 training

    The unglamorous aerobic base that moves resting HR, mitochondria, and long-term health risk more than anything else per hour.

    4 graded outcomes · 4 conditions · revised Jun 22, 2026

    Evidence grade A
  • Protein intake

    The macro with the strongest evidence in all of nutrition — most people building muscle need 1.6–2.2 g/kg, full stop.

    4 graded outcomes · 4 conditions · revised Jun 25, 2026

    Evidence grade A

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