Interaction

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• Acetyl-L-Carnitine (ALCAR) + L-Carnitine: work well together

  Overlapping carnitine pool; ALCAR is the more brain-penetrant form.

  Interaction · revised Jul 10, 2026

  CEvidence grade C
• Activated Charcoal + Oral contraceptives: separate the timing

  Adsorbs oral drugs — separate by hours to avoid failure.

  Interaction · revised Jul 10, 2026

  CEvidence grade C
• Alcohol + Benzodiazepines: use with caution

  Additive CNS and respiratory depression — a leading cause of sedative overdose.

  Interaction · revised Jul 10, 2026

  BEvidence grade B
• Alcohol + Opioids: use with caution

  Respiratory depression multiplies — a frequently fatal combination.

  Interaction · revised Jul 10, 2026

  BEvidence grade B
• Algae Omega-3 + Anticoagulants (warfarin): use with caution

  High-dose omega-3 adds bleeding risk on anticoagulants.

  Interaction · revised Jul 10, 2026

  BEvidence grade B
• Alpha-Lipoic Acid + Berberine: use with caution

  Stacking glucose-lowering agents multiplies monitoring needs.

  Interaction · revised Jul 10, 2026

  BEvidence grade B
• Alpha-Lipoic Acid + Metformin: use with caution

  Additive glucose lowering — watch for lows.

  Interaction · revised Jul 10, 2026

  BEvidence grade B
• American Ginseng + Anticoagulants (warfarin): use with caution

  May reduce warfarin effect — monitor INR.

  Interaction · revised Jul 10, 2026

  BEvidence grade B
• American Ginseng + Metformin: use with caution

  Additive glucose lowering.

  Interaction · revised Jul 10, 2026

  BEvidence grade B
• Aniracetam + Alpha-GPC: work well together

  Choline pairing is common with racetams.

  Interaction · revised Jul 10, 2026

  CEvidence grade C
• Apigenin + Glycine: work well together

  Two gentle, non-sedating onset levers.

  Interaction · revised Jul 10, 2026

  CEvidence grade C
• Apple Cider Vinegar + Metformin: use with caution

  Additive glucose lowering.

  Interaction · revised Jul 10, 2026

  BEvidence grade B
• Ashwagandha + Benzodiazepines: use with caution

  Additive sedation on top of the sedative's effect.

  Interaction · revised Jul 10, 2026

  BEvidence grade B
• Banaba (Corosolic Acid) + Metformin: use with caution

  Additive glucose lowering.

  Interaction · revised Jul 10, 2026

  BEvidence grade B
• Beetroot / Dietary Nitrate + Blood-pressure medications: use with caution

  Additive blood-pressure lowering.

  Interaction · revised Jul 10, 2026

  BEvidence grade B
• Benzodiazepines + Opioids: use with caution

  The FDA black-box pairing: additive respiratory depression and overdose risk.

  Interaction · revised Jul 10, 2026

  BEvidence grade B
• Berberine + Immunosuppressants: use with caution

  Berberine inhibits CYP3A4/P-gp, raising cyclosporine/tacrolimus levels.

  Interaction · revised Jul 10, 2026

  BEvidence grade B
• Berberine + Metformin: use with caution

  Additive glucose lowering — hypoglycemia risk; monitor.

  Interaction · revised Jul 10, 2026

  BEvidence grade B
• Bergamot (Citrus Bergamia) + Statins: use with caution

  Overlapping lipid mechanisms — coordinate.

  Interaction · revised Jul 10, 2026

  BEvidence grade B
• Beta-Alanine + Creatine: work well together

  Complementary energy systems — a common effective stack.

  Interaction · revised Jul 10, 2026

  CEvidence grade C
• Beta-Sitosterol + Saw Palmetto: work well together

  Common BPH stack.

  Interaction · revised Jul 10, 2026

  CEvidence grade C
• Betaine (TMG) + Creatine: work well together

  Both support cellular hydration/creatine status.

  Interaction · revised Jul 10, 2026

  CEvidence grade C
• Betaine HCl + PPIs: use with caution

  Directly opposes acid-suppressing drugs — don't combine.

  Interaction · revised Jul 10, 2026

  BEvidence grade B
• Bitter Melon + Metformin: use with caution

  Additive glucose lowering — hypoglycemia risk.

  Interaction · revised Jul 10, 2026

  BEvidence grade B
• Black Seed Oil (Nigella sativa) + Blood-pressure medications: use with caution

  Additive blood-pressure lowering.

  Interaction · revised Jul 10, 2026

  BEvidence grade B
• Boron + Tongkat Ali: work well together

  Common free-testosterone support stack.

  Interaction · revised Jul 10, 2026

  CEvidence grade C
• Boswellia + Curcumin (Turmeric): work well together

  Complementary anti-inflammatory pathways for joints.

  Interaction · revised Jul 10, 2026

  CEvidence grade C
• Bromelain + Anticoagulants (warfarin): use with caution

  Mild antiplatelet — additive bleeding risk.

  Interaction · revised Jul 10, 2026

  BEvidence grade B
• Caffeine + ADHD stimulants: use with caution

  Additive stimulation and cardiovascular strain on top of prescription stimulants.

  Interaction · revised Jul 10, 2026

  BEvidence grade B
• Caffeine + Melatonin: separate the timing

  Opposing circadian signals — the afternoon cutoff protects the melatonin window.

  Interaction · revised Jul 10, 2026

  CEvidence grade C
• Calcium + Corticosteroids: one depletes the other

  Long-term steroids reduce calcium absorption and bone density — repletion matters.

  Interaction · revised Jul 10, 2026

  BEvidence grade B
• Calcium + Levothyroxine: separate the timing

  Binds thyroid hormone — separate by 4 hours.

  Interaction · revised Jul 10, 2026

  CEvidence grade C
• Calcium + PPIs: separate the timing

  Calcium carbonate needs stomach acid — take citrate, or separate from acid-suppressing drugs.

  Interaction · revised Jul 10, 2026

  CEvidence grade C
• Calcium + Vitamin K2: work well together

  K2 directs calcium to bone, not arteries.

  Interaction · revised Jul 10, 2026

  CEvidence grade C
• Carnosine + Beta-Alanine: work well together

  Beta-alanine is the efficient muscle-carnosine precursor.

  Interaction · revised Jul 10, 2026

  CEvidence grade C
• Cat's Claw + Immunosuppressants: use with caution

  Immune modulation may oppose the drug.

  Interaction · revised Jul 10, 2026

  BEvidence grade B
• CBD (Cannabidiol) + Sedative: use with caution

  Additive sedation with other calming agents.

  Interaction · revised Jul 10, 2026

  BEvidence grade B
• CBD (Cannabidiol) + Statins: use with caution

  CBD inhibits CYP3A4 and can raise levels of many drugs, including some statins.

  Interaction · revised Jul 10, 2026

  BEvidence grade B
• Chlorella + Anticoagulants (warfarin): use with caution

  Vitamin-K content can antagonize warfarin — keep intake consistent.

  Interaction · revised Jul 10, 2026

  BEvidence grade B
• Chondroitin + Glucosamine: work well together

  The conventional joint pairing.

  Interaction · revised Jul 10, 2026

  CEvidence grade C
• Cinnamon + Anticoagulants (warfarin): use with caution

  Cassia cinnamon's coumarin adds to anticoagulant effect at high intake.

  Interaction · revised Jul 10, 2026

  BEvidence grade B
• Cinnamon + Metformin: use with caution

  Additive glucose lowering.

  Interaction · revised Jul 10, 2026

  BEvidence grade B
• Cocoa Flavanols + Blood-pressure medications: use with caution

  Additive blood-pressure lowering.

  Interaction · revised Jul 10, 2026

  BEvidence grade B
• Coenzyme Q10 + Anticoagulants (warfarin): use with caution

  May slightly reduce anticoagulant effect — monitor INR.

  Interaction · revised Jul 10, 2026

  BEvidence grade B
• Coenzyme Q10 + Statins: one depletes the other

  Statins lower CoQ10 ~30–50%; repletion may ease muscle symptoms.

  Interaction · revised Jul 10, 2026

  BEvidence grade B
• Collagen Peptides + Vitamin C: work well together

  The cofactor for collagen cross-linking — take together.

  Interaction · revised Jul 10, 2026

  CEvidence grade C
• Cranberry + D-Mannose: work well together

  Both target E. coli adhesion — common UTI-prevention pairing.

  Interaction · revised Jul 10, 2026

  CEvidence grade C
• Curcumin (Turmeric) + Anticoagulants (warfarin): use with caution

  Mild antiplatelet action — additive bleeding risk.

  Interaction · revised Jul 10, 2026

  BEvidence grade B
• Curcumin (Turmeric) + Antiplatelets: use with caution

  Curcumin has mild antiplatelet activity — additive bleeding risk.

  Interaction · revised Jul 10, 2026

  BEvidence grade B
• Curcumin (Turmeric) + Omega-3: work well together

  Complementary anti-inflammatory pathways for joints.

  Interaction · revised Jul 10, 2026

  CEvidence grade C
• Curcumin (Turmeric) + Piperine: work well together

  Piperine multiplies curcumin uptake ~20× — the classic pairing.

  Interaction · revised Jul 10, 2026

  CEvidence grade C
• D-Chiro-Inositol + Inositol (Myo-Inositol): work well together

  The 40:1 myo:D-chiro ratio is the evidence-based form.

  Interaction · revised Jul 10, 2026

  CEvidence grade C
• DIM (Diindolylmethane) + Calcium D-Glucarate: work well together

  Both support estrogen clearance pathways.

  Interaction · revised Jul 10, 2026

  CEvidence grade C
• Diosmin / Hesperidin + Horse Chestnut: work well together

  Complementary venous-tone mechanisms.

  Interaction · revised Jul 10, 2026

  CEvidence grade C
• Dong Quai + Anticoagulants (warfarin): use with caution

  Coumarins add bleeding risk.

  Interaction · revised Jul 10, 2026

  BEvidence grade B
• Epicatechin + Cocoa Flavanols: work well together

  Epicatechin is the active flavanol in cocoa.

  Interaction · revised Jul 10, 2026

  CEvidence grade C
• Fenugreek + Metformin: use with caution

  Additive glucose lowering.

  Interaction · revised Jul 10, 2026

  BEvidence grade B
• Feverfew + Magnesium: work well together

  Common migraine-prevention stack.

  Interaction · revised Jul 10, 2026

  CEvidence grade C
• Flaxseed / ALA Omega-3 + Omega-3: work well together

  ALA complements, but doesn't replace, EPA/DHA.

  Interaction · revised Jul 10, 2026

  CEvidence grade C
• GABA (Supplement) + L-Theanine: work well together

  Sometimes combined for calm; theanine is better supported.

  Interaction · revised Jul 10, 2026

  CEvidence grade C
• Garlic + Anticoagulants (warfarin): use with caution

  Antiplatelet action — additive bleeding risk.

  Interaction · revised Jul 10, 2026

  BEvidence grade B
• Garlic + Antiplatelets: use with caution

  Garlic's antiplatelet effect is additive with antiplatelet drugs.

  Interaction · revised Jul 10, 2026

  BEvidence grade B
• Garlic + Blood-pressure medications: use with caution

  Additive blood-pressure lowering.

  Interaction · revised Jul 10, 2026

  BEvidence grade B
• Ginger + Anticoagulants (warfarin): use with caution

  Mild antiplatelet — additive bleeding risk at high doses.

  Interaction · revised Jul 10, 2026

  BEvidence grade B
• Ginkgo Biloba + Anticoagulants (warfarin): use with caution

  Antiplatelet action — additive bleeding risk.

  Interaction · revised Jul 10, 2026

  BEvidence grade B
• Ginkgo Biloba + Antiplatelets: use with caution

  Ginkgo's antiplatelet action compounds aspirin/clopidogrel bleeding risk.

  Interaction · revised Jul 10, 2026

  BEvidence grade B
• Glucomannan + Levothyroxine: separate the timing

  Viscous fiber binds medications — separate by hours.

  Interaction · revised Jul 10, 2026

  CEvidence grade C
• Glutathione + Glycine: work well together

  Glycine is a glutathione building block.

  Interaction · revised Jul 10, 2026

  CEvidence grade C
• Glutathione + N-Acetylcysteine (NAC): work well together

  NAC supplies cysteine, the rate-limiting glutathione precursor.

  Interaction · revised Jul 10, 2026

  CEvidence grade C
• Glycerol + Electrolytes: work well together

  Paired for hyperhydration protocols.

  Interaction · revised Jul 10, 2026

  CEvidence grade C
• Glycine + Melatonin: separate the timing

  Both pre-bed and compatible — glycine 60–90 min out, melatonin ~30.

  Interaction · revised Jul 10, 2026

  CEvidence grade C
• Grape Seed Extract + Anticoagulants (warfarin): use with caution

  Mild antiplatelet — additive bleeding risk.

  Interaction · revised Jul 10, 2026

  BEvidence grade B
• Grapefruit + Benzodiazepines: use with caution

  Grapefruit raises levels of some benzodiazepines, deepening sedation.

  Interaction · revised Jul 10, 2026

  BEvidence grade B
• Grapefruit + Blood-pressure medications: use with caution

  Grapefruit raises several calcium-channel-blocker levels, exaggerating blood-pressure drops.

  Interaction · revised Jul 10, 2026

  BEvidence grade B
• Grapefruit + Immunosuppressants: use with caution

  Grapefruit sharply raises cyclosporine/tacrolimus levels — a classic dangerous food-drug interaction.

  Interaction · revised Jul 10, 2026

  BEvidence grade B
• Grapefruit + Statins: use with caution

  Grapefruit inhibits CYP3A4, raising levels of simvastatin/atorvastatin and the risk of muscle toxicity.

  Interaction · revised Jul 10, 2026

  BEvidence grade B
• Green Tea Extract (EGCG) + Anticoagulants (warfarin): use with caution

  Large amounts of green tea carry vitamin K and can affect anticoagulation — keep intake consistent.

  Interaction · revised Jul 10, 2026

  BEvidence grade B
• Guarana + Caffeine: use with caution

  It IS caffeine — don't double up.

  Interaction · revised Jul 10, 2026

  BEvidence grade B
• Gymnema Sylvestre + Metformin: use with caution

  Additive glucose lowering.

  Interaction · revised Jul 10, 2026

  BEvidence grade B
• Gynostemma (Jiaogulan) + Metformin: use with caution

  Additive glucose lowering.

  Interaction · revised Jul 10, 2026

  BEvidence grade B