Interaction · Supplement
Coenzyme Q10 + Statins: one depletes the other
Statins lower CoQ10 ~30–50%; repletion may ease muscle symptoms.
- Overall grade
- Grade B
- Last revised
- 0
- graded outcomes
- 0
- references listed
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- Watch with Coenzyme Q10: About Coenzyme Q10
The evidence in words
The interaction
Coenzyme Q10 and Statins — a depletion interaction. Statins lower CoQ10 ~30–50%; repletion may ease muscle symptoms.
What to do
Sustained use of one lowers the other over time. Monitor status and replete the depleted nutrient if it runs low — ideally guided by testing.
About Coenzyme Q10
CoQ10 (ubiquinone/ubiquinol) is a fat-soluble compound essential to the mitochondrial electron-transport chain and a cellular antioxidant. Levels fall with age and with statin use.
The bigger picture
Supplement–drug and supplement–supplement interactions are the reason a stack should be read as a system, not a list. This platform's interactions graph maps them; the medication side always belongs with the person who prescribes it.
Related reading
Entries that share this one's tags or conditions.
- Red Yeast Rice + Coenzyme Q10: one depletes the otherLike all statins, lowers CoQ10.Evidence grade B
- Bergamot (Citrus Bergamia) + Statins: use with cautionOverlapping lipid mechanisms — coordinate.Evidence grade B
- Calcium + Corticosteroids: one depletes the otherLong-term steroids reduce calcium absorption and bone density — repletion matters.Evidence grade B
- CBD (Cannabidiol) + Statins: use with cautionCBD inhibits CYP3A4 and can raise levels of many drugs, including some statins.Evidence grade B
Sources
This entry lists no references of its own — it is assembled from the entries it links to, whose sources are on their pages.
Last revised . A grade is this entry's reading of the evidence, not medical advice.