Grapefruit + Benzodiazepines: use with caution

Grapefruit raises levels of some benzodiazepines, deepening sedation.

Overall grade: Grade B
Last revised: Jul 10, 2026; 0
graded outcomes: 0
references listed

Assembled by the app from other entries in this library. It adds no evidence of its own — follow the links to the entries it draws on.

What is uncertain

Read off the same rows as above. Nothing here is added that the entry does not itself record.

Watch with Grapefruit: About Grapefruit

The evidence in words

The interaction

Grapefruit and Benzodiazepines — a caution interaction. Grapefruit raises levels of some benzodiazepines, deepening sedation.

What to do

Do not combine these casually. The interaction can matter clinically — bring it to the prescriber who manages the medication before stacking them.

About Grapefruit

Grapefruit and Benzodiazepines have a documented interaction worth knowing before combining them.

The bigger picture

Supplement–drug and supplement–supplement interactions are the reason a stack should be read as a system, not a list. This platform's interactions graph maps them; the medication side always belongs with the person who prescribes it.

Entries that share this one's tags or conditions.

Alcohol + Benzodiazepines: use with cautionAdditive CNS and respiratory depression — a leading cause of sedative overdose.Evidence grade B
Ashwagandha + Benzodiazepines: use with cautionAdditive sedation on top of the sedative's effect.Evidence grade B
Benzodiazepines + Opioids: use with cautionThe FDA black-box pairing: additive respiratory depression and overdose risk.Evidence grade B
Grapefruit + Blood-pressure medications: use with cautionGrapefruit raises several calcium-channel-blocker levels, exaggerating blood-pressure drops.Evidence grade B

Sources

This entry lists no references of its own — it is assembled from the entries it links to, whose sources are on their pages.

Last revised Jul 10, 2026. A grade is this entry's reading of the evidence, not medical advice.