Interaction · Supplement
Berberine + Immunosuppressants: use with caution
Berberine inhibits CYP3A4/P-gp, raising cyclosporine/tacrolimus levels.
- Overall grade
- Grade B
- Last revised
- 0
- graded outcomes
- 0
- references listed
Assembled by the app from other entries in this library. It adds no evidence of its own — follow the links to the entries it draws on.
What is uncertain
Read off the same rows as above. Nothing here is added that the entry does not itself record.
- Watch with Berberine: About Berberine
The evidence in words
The interaction
Berberine and Immunosuppressants — a caution interaction. Berberine inhibits CYP3A4/P-gp, raising cyclosporine/tacrolimus levels.
What to do
Do not combine these casually. The interaction can matter clinically — bring it to the prescriber who manages the medication before stacking them.
About Berberine
Berberine is an alkaloid from several plants (goldenseal, barberry) with pharmacologic effects on glucose and lipid metabolism rivaling some prescription agents.
The bigger picture
Supplement–drug and supplement–supplement interactions are the reason a stack should be read as a system, not a list. This platform's interactions graph maps them; the medication side always belongs with the person who prescribes it.
Related reading
Entries that share this one's tags or conditions.
- Alpha-Lipoic Acid + Berberine: use with cautionStacking glucose-lowering agents multiplies monitoring needs.Evidence grade B
- Berberine + Metformin: use with cautionAdditive glucose lowering — hypoglycemia risk; monitor.Evidence grade B
- Cat's Claw + Immunosuppressants: use with cautionImmune modulation may oppose the drug.Evidence grade B
- Grapefruit + Immunosuppressants: use with cautionGrapefruit sharply raises cyclosporine/tacrolimus levels — a classic dangerous food-drug interaction.Evidence grade B
Sources
This entry lists no references of its own — it is assembled from the entries it links to, whose sources are on their pages.
Last revised . A grade is this entry's reading of the evidence, not medical advice.