Safety · Supplement
CBD (Cannabidiol): side effects, safety & interactions
Generally well tolerated (fatigue, diarrhea, appetite changes); high doses can raise liver enzymes. Clinically important
- Overall grade
- Grade B
- Last revised
- 0
- graded outcomes
- 2
- references listed
Assembled by the app from other entries in this library. It adds no evidence of its own — follow the links to the entries it draws on.
The evidence in words
Safety profile
Generally well tolerated (fatigue, diarrhea, appetite changes); high doses can raise liver enzymes. Clinically important: CBD inhibits CYP3A4/CYP2C19 and can raise levels of many drugs — check interactions before combining.
Interactions to respect
Statins — CBD inhibits CYP3A4 and can raise levels of many drugs, including some statins. · Sedative — Additive sedation with other calming agents.
What CBD (Cannabidiol) is
Cannabidiol is a non-psychoactive compound from cannabis/hemp; a purified prescription form (Epidiolex) treats rare epilepsies.
The honest bottom line
Proven for certain epilepsies; a reasonable, if unsettled, option for anxiety and sleep — if you buy tested product and respect the drug interactions.
Related reading
Entries that share this one's tags or conditions.
- CBD (Cannabidiol) for AnxietyEvidence grade B — Higher dosesEvidence grade B
- CBD (Cannabidiol) for SleepEvidence grade C — IndirectEvidence grade C
- CBD (Cannabidiol)A non-intoxicating cannabinoid with rock-solid epilepsy evidence and promising-but-unsettled anxiety and sleep data.Evidence grade B
- CBD (Cannabidiol) for Chronic painEvidence grade C — UnclearEvidence grade C
Sources
As this entry records them: title, journal and year. None carries a DOI or PubMed id, so none is linked as a verified paper. Each link searches PubMed for the title; check that what you find is what the entry describes.
- 1.Cannabidiol in Dravet syndrome (Epidiolex) — N Engl J Med, 2017. Search PubMed (opens in a new tab)
- 2.CBD for anxiety: review — Neurotherapeutics, 2015. Search PubMed (opens in a new tab)
Last revised . A grade is this entry's reading of the evidence, not medical advice.