Evidence brief · Supplement
CBD (Cannabidiol) for Anxiety
Evidence grade B — Higher doses
- Overall grade
- Grade B
- Last revised
- 1
- graded outcome
- 2
- references listed
Assembled by the app from other entries in this library. It adds no evidence of its own — follow the links to the entries it draws on.
1 at grade B — 1 graded row
What is known
Each outcome with its grade (how strong the evidence is, A to D), the size of the effect where the entry records one, and how often studies agree.
- AnxietyEvidence grade B
Higher doses
Moderatemixed
What is uncertain
Read off the same rows as above. Nothing here is added that the entry does not itself record.
- Studies disagree: Anxiety (mixed agreement).
The evidence in words
The verdict
For anxiety, CBD (Cannabidiol) earns evidence grade B (moderate effect, mixed consistency) — there is real evidence here. Higher doses
How it might work
It acts on multiple targets — serotonin 5-HT1A, TRPV1, and endocannabinoid tone — rather than the CB1 'high' receptor, giving anxiolytic and anticonvulsant effects.
How to use it
Consumer anxiety/sleep doses in studies are often higher than product labels suggest (tens to hundreds of mg). Start low, choose third-party-tested products with a COA, and separate from other medications.
Safety & cautions
Generally well tolerated (fatigue, diarrhea, appetite changes); high doses can raise liver enzymes. Clinically important: CBD inhibits CYP3A4/CYP2C19 and can raise levels of many drugs — check interactions before combining.
Bottom line
Proven for certain epilepsies; a reasonable, if unsettled, option for anxiety and sleep — if you buy tested product and respect the drug interactions.
Goes with
- CBD (Cannabidiol)Read the full CBD (Cannabidiol) monographEvidence grade B
Related reading
Entries that share this one's tags or conditions.
- CBD (Cannabidiol) for SleepEvidence grade C — IndirectEvidence grade C
- CBD (Cannabidiol) for Chronic painEvidence grade C — UnclearEvidence grade C
- CBD (Cannabidiol) for Rare epilepsies (Rx)Evidence grade A — Purified, prescriptionEvidence grade A
- CBD (Cannabidiol): side effects, safety & interactionsGenerally well tolerated (fatigue, diarrhea, appetite changes); high doses can raise liver enzymes. Clinically importantEvidence grade B
Sources
As this entry records them: title, journal and year. None carries a DOI or PubMed id, so none is linked as a verified paper. Each link searches PubMed for the title; check that what you find is what the entry describes.
- 1.Cannabidiol in Dravet syndrome (Epidiolex) — N Engl J Med, 2017. Search PubMed (opens in a new tab)
- 2.CBD for anxiety: review — Neurotherapeutics, 2015. Search PubMed (opens in a new tab)
Last revised . A grade is this entry's reading of the evidence, not medical advice.