Safety · Supplement
Alpha-GPC: side effects, safety & interactions
Generally tolerated; the observational stroke-risk signal is unresolved and worth noting for high chronic use.
- Overall grade
- Grade C
- Last revised
- 0
- graded outcomes
- 0
- references listed
Assembled by the app from other entries in this library. It adds no evidence of its own — follow the links to the entries it draws on.
The evidence in words
Safety profile
Generally tolerated; the observational stroke-risk signal is unresolved and worth noting for high chronic use.
Interactions to respect
No major interactions are on record for Alpha-GPC at typical doses, but tell your clinician about everything you take.
What Alpha-GPC is
Alpha-GPC (L-alpha-glycerylphosphorylcholine) is a highly bioavailable choline source studied for cognition and, intriguingly, for physical power output.
The honest bottom line
More interesting for power output than for everyday cognition. 300–600 mg; keep an eye on the unresolved cardiovascular signal if using chronically.
Related reading
Entries that share this one's tags or conditions.
- Citicoline (CDP-Choline): side effects, safety & interactionsWell tolerated; occasional headache or GI upset.Evidence grade C
- Alpha-GPCA choline donor with a little power-output data and thin cognition evidence outside dementia settings.Evidence grade C
- Alpha-GPC for Cognition (healthy)Evidence grade D — WeakEvidence grade D
- Alpha-GPC for Power / force outputEvidence grade C — AcuteEvidence grade C
Sources
This entry lists no references of its own — it is assembled from the entries it links to, whose sources are on their pages.
Last revised . A grade is this entry's reading of the evidence, not medical advice.