Compound or practice · Supplement
Alpha-GPC
A choline donor with a little power-output data and thin cognition evidence outside dementia settings.
- Overall grade
- Grade C
- Last revised
- 2
- graded outcomes
- 0
- references listed
A structured monograph in Prometheus's bundled library. Its grades are the monograph's own reading of the evidence, not a peer-reviewed review.
1 at grade C · 1 at grade D — 2 graded rows
What is known
Each outcome with its grade (how strong the evidence is, A to D), the size of the effect where the entry records one, and how often studies agree.
- Power / force outputEvidence grade C
Acute
Smallmixed
- Cognition (healthy)Evidence grade D
Weak
Triviallow
What is uncertain
Read off the same rows as above. Nothing here is added that the entry does not itself record.
- Thin evidence: Power / force output (grade C); Cognition (healthy) (grade D).
The evidence in words
What it is
Alpha-GPC (L-alpha-glycerylphosphorylcholine) is a highly bioavailable choline source studied for cognition and, intriguingly, for physical power output.
How it works
It raises choline availability for acetylcholine and appears to support growth-hormone and power responses acutely, the basis for its pre-workout use.
What the evidence shows
Cognition evidence in healthy people is weak; there is better (though still limited) data in cognitive decline. Small studies show acute improvements in power/force output, giving it a niche as a pre-workout cholinergic. A debated observational signal links high alpha-GPC intake to stroke risk, warranting caution pending clarification.
How to use it
300–600 mg, often pre-workout or split for cognition.
Safety & interactions
Generally tolerated; the observational stroke-risk signal is unresolved and worth noting for high chronic use.
Bottom line
More interesting for power output than for everyday cognition. 300–600 mg; keep an eye on the unresolved cardiovascular signal if using chronically.
How it is used
As the entry records it, from the studies it summarises. Not a recommendation for you — doses that suit a trial population may not suit you.
- Standard
- 300–600 mg, pre-workout or split.
Related reading
Entries that share this one's tags or conditions.
- Alpha-GPC for Cognition (healthy)Evidence grade D — WeakEvidence grade D
- Alpha-GPC for Power / force outputEvidence grade C — AcuteEvidence grade C
- Alpha-GPC: dosage and how to take it300–600 mg, pre-workout or split.Evidence grade C
- Alpha-GPC: side effects, safety & interactionsGenerally tolerated; the observational stroke-risk signal is unresolved and worth noting for high chronic use.Evidence grade C
Sources
This entry lists no references of its own.
Last revised . A grade is this entry's reading of the evidence, not medical advice.