Evidence brief · Supplement
Alpha-GPC for Cognition (healthy)
Evidence grade D — Weak
- Overall grade
- Grade D
- Last revised
- 1
- graded outcome
- 0
- references listed
Assembled by the app from other entries in this library. It adds no evidence of its own — follow the links to the entries it draws on.
1 at grade D — 1 graded row
What is known
Each outcome with its grade (how strong the evidence is, A to D), the size of the effect where the entry records one, and how often studies agree.
- Cognition (healthy)Evidence grade D
Weak
Triviallow
What is uncertain
Read off the same rows as above. Nothing here is added that the entry does not itself record.
- Thin evidence: Cognition (healthy) (grade D).
The evidence in words
The verdict
For cognition (healthy), Alpha-GPC earns evidence grade D (trivial effect, low consistency) — the evidence does not support the claim. Weak
How it might work
It raises choline availability for acetylcholine and appears to support growth-hormone and power responses acutely, the basis for its pre-workout use.
How to use it
300–600 mg, often pre-workout or split for cognition.
Safety & cautions
Generally tolerated; the observational stroke-risk signal is unresolved and worth noting for high chronic use.
Bottom line
More interesting for power output than for everyday cognition. 300–600 mg; keep an eye on the unresolved cardiovascular signal if using chronically.
How it is used
As the entry records it, from the studies it summarises. Not a recommendation for you — doses that suit a trial population may not suit you.
- Standard
- 300–600 mg, pre-workout or split.
Goes with
- Alpha-GPCRead the full Alpha-GPC monographEvidence grade C
Related reading
Entries that share this one's tags or conditions.
- Alpha-GPC for Power / force outputEvidence grade C — AcuteEvidence grade C
- Alpha-GPC: dosage and how to take it300–600 mg, pre-workout or split.Evidence grade C
- Alpha-GPC: side effects, safety & interactionsGenerally tolerated; the observational stroke-risk signal is unresolved and worth noting for high chronic use.Evidence grade C
- Citicoline (CDP-Choline) for Attention / memoryEvidence grade C — ModestEvidence grade C
Sources
This entry lists no references of its own — it is assembled from the entries it links to, whose sources are on their pages.
Last revised . A grade is this entry's reading of the evidence, not medical advice.