Safety · Supplement
Betaine (TMG): side effects, safety & interactions
Well tolerated; can raise LDL/triglycerides slightly at high doses.
- Overall grade
- Grade C
- Last revised
- 0
- graded outcomes
- 0
- references listed
Assembled by the app from other entries in this library. It adds no evidence of its own — follow the links to the entries it draws on.
The evidence in words
Safety profile
Well tolerated; can raise LDL/triglycerides slightly at high doses.
Interactions to respect
No major interactions are on record for Betaine (TMG) at typical doses, but tell your clinician about everything you take.
What Betaine (TMG) is
Betaine (trimethylglycine) is an amino-acid derivative that acts as a cellular osmolyte and a methyl donor in homocysteine metabolism.
The honest bottom line
A cheap maybe-ergogenic. 2.5 g/day for a small shot at better power/composition; also lowers homocysteine.
Related reading
Entries that share this one's tags or conditions.
- Betaine (TMG)An osmolyte and methyl donor with modest power/body-composition data and reliable homocysteine lowering.Evidence grade C
- DMG (Dimethylglycine): side effects, safety & interactionsGenerally safe.Evidence grade D
- Agmatine: side effects, safety & interactionsLimited human safety data; generally tolerated short-term.Evidence grade D
- Alpha-GPC: side effects, safety & interactionsGenerally tolerated; the observational stroke-risk signal is unresolved and worth noting for high chronic use.Evidence grade C
Sources
This entry lists no references of its own — it is assembled from the entries it links to, whose sources are on their pages.
Last revised . A grade is this entry's reading of the evidence, not medical advice.