Compound or practice · Supplement
UC-II (Undenatured Collagen II)
A tiny-dose collagen that works by immune tolerance, not building blocks — decent joint-pain evidence.
- Overall grade
- Grade B
- Last revised
- 1
- graded outcome
- 0
- references listed
A structured monograph in Prometheus's bundled library. Its grades are the monograph's own reading of the evidence, not a peer-reviewed review.
1 at grade B — 1 graded row
What is known
Each outcome with its grade (how strong the evidence is, A to D), the size of the effect where the entry records one, and how often studies agree.
- Osteoarthritis pain/functionEvidence grade B
40 mg/day
Moderatemixed
What is uncertain
Read off the same rows as above. Nothing here is added that the entry does not itself record.
- Studies disagree: Osteoarthritis pain/function (mixed agreement).
The evidence in words
What it is
UC-II is undenatured type-II collagen dosed at just 40 mg, distinct from hydrolyzed collagen peptides.
How it works
It works via oral tolerance — small amounts train the immune system to dampen joint inflammation, not by supplying collagen substrate.
What the evidence shows
Several trials show 40 mg/day UC-II improves osteoarthritis pain and function, in some studies outperforming glucosamine+chondroitin. Small but reasonably consistent for a joint supplement.
Safety & interactions
Very safe at 40 mg.
Bottom line
A distinct, low-dose collagen with genuinely decent OA evidence — don't confuse it with collagen peptides. 40 mg/day.
Related reading
Entries that share this one's tags or conditions.
- Eggshell Membrane (NEM)A collagen/glycosaminoglycan joint supplement with modest, mostly industry-funded evidence.Evidence grade C
- BoswelliaAn anti-inflammatory resin with some of the better osteoarthritis-pain data among botanicals.Evidence grade B
- Boswellia for OsteoarthritisEvidence grade B — Reasonable RCT supportEvidence grade B
- ChondroitinGlucosamine's usual partner — similarly modest and contested for osteoarthritis.Evidence grade C
Sources
This entry lists no references of its own.
Last revised . A grade is this entry's reading of the evidence, not medical advice.