Compound or practice · Supplement
Chondroitin
Glucosamine's usual partner — similarly modest and contested for osteoarthritis.
- Overall grade
- Grade C
- Last revised
- 1
- graded outcome
- 0
- references listed
A structured monograph in Prometheus's bundled library. Its grades are the monograph's own reading of the evidence, not a peer-reviewed review.
1 at grade C — 1 graded row
What is known
Each outcome with its grade (how strong the evidence is, A to D), the size of the effect where the entry records one, and how often studies agree.
- Osteoarthritis pain/functionEvidence grade C
Grade varies with quality
Smallmixed
What is uncertain
Read off the same rows as above. Nothing here is added that the entry does not itself record.
- Thin evidence: Osteoarthritis pain/function (grade C).
Interactions
Documented pairings with supplements and medicines. A medicine on this list is a conversation for whoever prescribes it.
GlucosamineWorks together
The conventional joint pairing.
The evidence in words
What it is
Chondroitin sulfate is a cartilage glycosaminoglycan, typically paired with glucosamine for joint support.
How it works
It may support cartilage matrix and have anti-inflammatory effects; like glucosamine, mechanism and outcomes don't align cleanly.
What the evidence shows
Some trials and meta-analyses show small pain/function benefits in osteoarthritis (pharmaceutical-grade chondroitin fares better); others are null. Quality of product varies widely. A reasonable component of a joint trial, not a proven agent.
How to use it
800–1,200 mg/day, usually with glucosamine, for 8–12 weeks.
Safety & interactions
Well tolerated. Glucosamine — The conventional joint pairing.
Bottom line
Part of the glucosamine-chondroitin trial for OA. Modest and inconsistent; product quality matters.
How it is used
As the entry records it, from the studies it summarises. Not a recommendation for you — doses that suit a trial population may not suit you.
- Standard
- 800–1,200 mg/day with glucosamine.
Goes with
- GlucosamineThe conventional joint pairing.Evidence grade C
Related reading
Entries that share this one's tags or conditions.
- BoswelliaAn anti-inflammatory resin with some of the better osteoarthritis-pain data among botanicals.Evidence grade B
- Boswellia for OsteoarthritisEvidence grade B — Reasonable RCT supportEvidence grade B
- Glucosamine for OsteoarthritisEvidence grade C — Trial for 8–12 weeksEvidence grade C
- Boswellia for Osteoarthritis pain/functionEvidence grade B — Standardized extractsEvidence grade B
Sources
This entry lists no references of its own.
Last revised . A grade is this entry's reading of the evidence, not medical advice.