Compound or practice · Supplement
Eggshell Membrane (NEM)
A collagen/glycosaminoglycan joint supplement with modest, mostly industry-funded evidence.
- Overall grade
- Grade C
- Last revised
- 1
- graded outcome
- 0
- references listed
A structured monograph in Prometheus's bundled library. Its grades are the monograph's own reading of the evidence, not a peer-reviewed review.
1 at grade C — 1 graded row
What is known
Each outcome with its grade (how strong the evidence is, A to D), the size of the effect where the entry records one, and how often studies agree.
- Joint pain / stiffnessEvidence grade C
500 mg/day
Smallmixed
What is uncertain
Read off the same rows as above. Nothing here is added that the entry does not itself record.
- Thin evidence: Joint pain / stiffness (grade C).
The evidence in words
What it is
Natural eggshell membrane (NEM) supplies collagen, hyaluronic acid, and glycosaminoglycans for joints.
How it works
It provides connective-tissue substrates and may have anti-inflammatory effects.
What the evidence shows
Small trials (often manufacturer-linked) show reduced joint pain and stiffness at 500 mg/day within weeks; independent replication is limited. Modest and low-risk.
Safety & interactions
Safe; egg-allergy caution.
Bottom line
A convenient once-daily joint option with modest, mostly industry evidence. Reasonable to trial for OA.
Related reading
Entries that share this one's tags or conditions.
- UC-II (Undenatured Collagen II)A tiny-dose collagen that works by immune tolerance, not building blocks — decent joint-pain evidence.Evidence grade B
- BoswelliaAn anti-inflammatory resin with some of the better osteoarthritis-pain data among botanicals.Evidence grade B
- Boswellia for OsteoarthritisEvidence grade B — Reasonable RCT supportEvidence grade B
- ChondroitinGlucosamine's usual partner — similarly modest and contested for osteoarthritis.Evidence grade C
Sources
This entry lists no references of its own.
Last revised . A grade is this entry's reading of the evidence, not medical advice.