Interaction · Supplement
Magnesium + PPIs: one depletes the other
Prolonged PPI use can drive magnesium clinically low.
- Overall grade
- Grade B
- Last revised
- 0
- graded outcomes
- 0
- references listed
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What is uncertain
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- Watch with Magnesium: About Magnesium
The evidence in words
The interaction
Magnesium and PPIs — a depletion interaction. Prolonged PPI use can drive magnesium clinically low.
What to do
Sustained use of one lowers the other over time. Monitor status and replete the depleted nutrient if it runs low — ideally guided by testing.
About Magnesium
Magnesium is an essential mineral concentrated in bone and inside cells, where it is a cofactor for over 300 enzymes including every reaction that uses ATP. Intakes below the requirement are common on Western diets. Forms differ mainly in absorption and bowel tolerance: glycinate and citrate absorb well, oxide is mostly a laxative, and L-threonate is marketed for the brain.
The bigger picture
Supplement–drug and supplement–supplement interactions are the reason a stack should be read as a system, not a list. This platform's interactions graph maps them; the medication side always belongs with the person who prescribes it.
Related reading
Entries that share this one's tags or conditions.
- Iron + PPIs: one depletes the otherLow stomach acid from PPIs reduces non-heme iron absorption over time.Evidence grade B
- Magnesium + Diuretics: one depletes the otherLoop and thiazide diuretics waste magnesium — a common cause of low levels.Evidence grade B
- Vitamin B12 + PPIs: one depletes the otherAcid suppression starves the absorption pathway over years.Evidence grade B
- Betaine HCl + PPIs: use with cautionDirectly opposes acid-suppressing drugs — don't combine.Evidence grade B
Sources
This entry lists no references of its own — it is assembled from the entries it links to, whose sources are on their pages.
Last revised . A grade is this entry's reading of the evidence, not medical advice.