Interaction · Supplement
Magnesium + Diuretics: one depletes the other
Loop and thiazide diuretics waste magnesium — a common cause of low levels.
- Overall grade
- Grade B
- Last revised
- 0
- graded outcomes
- 0
- references listed
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What is uncertain
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- Watch with Magnesium: About Magnesium
The evidence in words
The interaction
Magnesium and Diuretics — a depletion interaction. Loop and thiazide diuretics waste magnesium — a common cause of low levels.
What to do
Sustained use of one lowers the other over time. Monitor status and replete the depleted nutrient if it runs low — ideally guided by testing.
About Magnesium
Magnesium is an essential mineral concentrated in bone and inside cells, where it is a cofactor for over 300 enzymes including every reaction that uses ATP. Intakes below the requirement are common on Western diets. Forms differ mainly in absorption and bowel tolerance: glycinate and citrate absorb well, oxide is mostly a laxative, and L-threonate is marketed for the brain.
The bigger picture
Supplement–drug and supplement–supplement interactions are the reason a stack should be read as a system, not a list. This platform's interactions graph maps them; the medication side always belongs with the person who prescribes it.
Related reading
Entries that share this one's tags or conditions.
- Magnesium + PPIs: one depletes the otherProlonged PPI use can drive magnesium clinically low.Evidence grade B
- Zinc + Diuretics: one depletes the otherThiazide diuretics increase urinary zinc loss over time.Evidence grade B
- Calcium + Corticosteroids: one depletes the otherLong-term steroids reduce calcium absorption and bone density — repletion matters.Evidence grade B
- Coenzyme Q10 + Statins: one depletes the otherStatins lower CoQ10 ~30–50%; repletion may ease muscle symptoms.Evidence grade B
Sources
This entry lists no references of its own — it is assembled from the entries it links to, whose sources are on their pages.
Last revised . A grade is this entry's reading of the evidence, not medical advice.