Interaction · Supplement
Zinc + Diuretics: one depletes the other
Thiazide diuretics increase urinary zinc loss over time.
- Overall grade
- Grade B
- Last revised
- 0
- graded outcomes
- 0
- references listed
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What is uncertain
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- Watch with Zinc: About Zinc
The evidence in words
The interaction
Zinc and Diuretics — a depletion interaction. Thiazide diuretics increase urinary zinc loss over time.
What to do
Sustained use of one lowers the other over time. Monitor status and replete the depleted nutrient if it runs low — ideally guided by testing.
About Zinc
Zinc is an essential trace mineral and structural cofactor in hundreds of enzymes and transcription factors. Mild deficiency exists, especially in vegetarians and older adults, because phytates in grains and legumes reduce absorption.
The bigger picture
Supplement–drug and supplement–supplement interactions are the reason a stack should be read as a system, not a list. This platform's interactions graph maps them; the medication side always belongs with the person who prescribes it.
Related reading
Entries that share this one's tags or conditions.
- Magnesium + Diuretics: one depletes the otherLoop and thiazide diuretics waste magnesium — a common cause of low levels.Evidence grade B
- Zinc + Copper: one depletes the otherHigh-dose zinc induces copper deficiency — balance ~15:1 or test.Evidence grade B
- Calcium + Corticosteroids: one depletes the otherLong-term steroids reduce calcium absorption and bone density — repletion matters.Evidence grade B
- Coenzyme Q10 + Statins: one depletes the otherStatins lower CoQ10 ~30–50%; repletion may ease muscle symptoms.Evidence grade B
Sources
This entry lists no references of its own — it is assembled from the entries it links to, whose sources are on their pages.
Last revised . A grade is this entry's reading of the evidence, not medical advice.