Interaction · Supplement
Vitamin B12 + PPIs: one depletes the other
Acid suppression starves the absorption pathway over years.
- Overall grade
- Grade B
- Last revised
- 0
- graded outcomes
- 0
- references listed
Assembled by the app from other entries in this library. It adds no evidence of its own — follow the links to the entries it draws on.
What is uncertain
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- Watch with Vitamin B12: About Vitamin B12
The evidence in words
The interaction
Vitamin B12 and PPIs — a depletion interaction. Acid suppression starves the absorption pathway over years.
What to do
Sustained use of one lowers the other over time. Monitor status and replete the depleted nutrient if it runs low — ideally guided by testing.
About Vitamin B12
B12 is a water-soluble vitamin found almost exclusively in animal foods. It is essential for red-blood-cell formation, DNA synthesis, and the myelin sheath around nerves. Because the liver stores years' worth, deficiency develops slowly and can be missed until it causes anemia or irreversible nerve damage.
The bigger picture
Supplement–drug and supplement–supplement interactions are the reason a stack should be read as a system, not a list. This platform's interactions graph maps them; the medication side always belongs with the person who prescribes it.
Related reading
Entries that share this one's tags or conditions.
- Iron + PPIs: one depletes the otherLow stomach acid from PPIs reduces non-heme iron absorption over time.Evidence grade B
- Magnesium + PPIs: one depletes the otherProlonged PPI use can drive magnesium clinically low.Evidence grade B
- Vitamin B12 + Metformin: one depletes the otherLong-term metformin lowers B12 in up to a third of users — test annually.Evidence grade B
- Betaine HCl + PPIs: use with cautionDirectly opposes acid-suppressing drugs — don't combine.Evidence grade B
Sources
This entry lists no references of its own — it is assembled from the entries it links to, whose sources are on their pages.
Last revised . A grade is this entry's reading of the evidence, not medical advice.