Interaction · Supplement
Iron + PPIs: one depletes the other
Low stomach acid from PPIs reduces non-heme iron absorption over time.
- Overall grade
- Grade B
- Last revised
- 0
- graded outcomes
- 0
- references listed
Assembled by the app from other entries in this library. It adds no evidence of its own — follow the links to the entries it draws on.
What is uncertain
Read off the same rows as above. Nothing here is added that the entry does not itself record.
- Watch with Iron: About Iron
The evidence in words
The interaction
Iron and PPIs — a depletion interaction. Low stomach acid from PPIs reduces non-heme iron absorption over time.
What to do
Sustained use of one lowers the other over time. Monitor status and replete the depleted nutrient if it runs low — ideally guided by testing.
About Iron
Iron is the oxygen-carrying metal at the center of hemoglobin. Deficiency (low ferritin, then anemia) is the world's most common nutrient deficiency, especially in menstruating women, endurance athletes, and plant-based eaters. The body has no route to excrete excess, so iron status must be earned, not guessed.
The bigger picture
Supplement–drug and supplement–supplement interactions are the reason a stack should be read as a system, not a list. This platform's interactions graph maps them; the medication side always belongs with the person who prescribes it.
Related reading
Entries that share this one's tags or conditions.
- Magnesium + PPIs: one depletes the otherProlonged PPI use can drive magnesium clinically low.Evidence grade B
- Vitamin B12 + PPIs: one depletes the otherAcid suppression starves the absorption pathway over years.Evidence grade B
- Betaine HCl + PPIs: use with cautionDirectly opposes acid-suppressing drugs — don't combine.Evidence grade B
- Calcium + Corticosteroids: one depletes the otherLong-term steroids reduce calcium absorption and bone density — repletion matters.Evidence grade B
Sources
This entry lists no references of its own — it is assembled from the entries it links to, whose sources are on their pages.
Last revised . A grade is this entry's reading of the evidence, not medical advice.