Supplements for women's health

14 compounds relevant to women's health, ranked by overall evidence grade.

Overall grade: Grade B
Last revised: Jul 10, 2026; 14
graded outcomes: 0
references listed

Assembled by the app from other entries in this library. It adds no evidence of its own — follow the links to the entries it draws on.

5 at grade B · 6 at grade C · 3 at grade D — 14 graded rows

What is known

Each outcome with its grade (how strong the evidence is, A to D), the size of the effect where the entry records one, and how often studies agree.

Outcome	Grade	Effect size	Agreement
Vitex (Chasteberry)One of the better-supported botanicals for PMS and cyclical breast pain, working through prolactin.	Evidence grade B	Unclear	mixed
CranberryGenuinely reduces recurrent UTIs via proanthocyanidins — prevention, not treatment.	Evidence grade B	Unclear	mixed
Inositol (Myo-Inositol)A sugar-alcohol with genuinely good evidence in PCOS and reasonable anxiety/OCD signals.	Evidence grade B	Unclear	mixed
Soy IsoflavonesPhytoestrogens with real, modest evidence for menopausal hot flashes — and no, they don't feminize men.	Evidence grade B	Unclear	mixed
D-Chiro-InositolAn inositol isomer for PCOS — best used in the physiological 40:1 ratio with myo-inositol, not alone at high doses.	Evidence grade B	Unclear	mixed
Black CohoshA menopausal hot-flash botanical with genuinely divided trials and rare liver-safety signals.	Evidence grade C	Unclear	mixed
D-MannoseA simple sugar that helps flush UTI-causing E. coli — promising early data for prevention.	Evidence grade C	Unclear	mixed
DIM (Diindolylmethane)A cruciferous-vegetable metabolite that shifts estrogen metabolism — real biomarker effects, thin clinical data.	Evidence grade C	Unclear	mixed
Evening Primrose Oil (GLA)A GLA source popular for PMS, breast pain, and eczema — mostly modest or null on rigorous review.	Evidence grade C	Unclear	mixed
Red CloverAnother isoflavone source for menopause with weaker, more inconsistent data than soy.	Evidence grade C	Unclear	mixed
SpearmintA mint tea with a genuine anti-androgen signal for hirsutism/PCOS and early memory data.	Evidence grade C	Unclear	mixed
Calcium D-GlucarateA detox-pathway supplement with sound mechanism and almost no human outcome data.	Evidence grade D	Unclear	mixed
ShatavariAn Ayurvedic women's-health tonic with mostly traditional use and a lactation signal.	Evidence grade D	Unclear	mixed
Dong QuaiA classic 'female tonic' whose menopause evidence is weak — and it interacts with blood thinners.	Evidence grade D	Unclear	mixed

Vitex (Chasteberry)Evidence grade B
One of the better-supported botanicals for PMS and cyclical breast pain, working through prolactin.
Unclearmixed
CranberryEvidence grade B
Genuinely reduces recurrent UTIs via proanthocyanidins — prevention, not treatment.
Unclearmixed
Inositol (Myo-Inositol)Evidence grade B
A sugar-alcohol with genuinely good evidence in PCOS and reasonable anxiety/OCD signals.
Unclearmixed
Soy IsoflavonesEvidence grade B
Phytoestrogens with real, modest evidence for menopausal hot flashes — and no, they don't feminize men.
Unclearmixed
D-Chiro-InositolEvidence grade B
An inositol isomer for PCOS — best used in the physiological 40:1 ratio with myo-inositol, not alone at high doses.
Unclearmixed
Black CohoshEvidence grade C
A menopausal hot-flash botanical with genuinely divided trials and rare liver-safety signals.
Unclearmixed
D-MannoseEvidence grade C
A simple sugar that helps flush UTI-causing E. coli — promising early data for prevention.
Unclearmixed
DIM (Diindolylmethane)Evidence grade C
A cruciferous-vegetable metabolite that shifts estrogen metabolism — real biomarker effects, thin clinical data.
Unclearmixed
Evening Primrose Oil (GLA)Evidence grade C
A GLA source popular for PMS, breast pain, and eczema — mostly modest or null on rigorous review.
Unclearmixed
Red CloverEvidence grade C
Another isoflavone source for menopause with weaker, more inconsistent data than soy.
Unclearmixed
SpearmintEvidence grade C
A mint tea with a genuine anti-androgen signal for hirsutism/PCOS and early memory data.
Unclearmixed
Calcium D-GlucarateEvidence grade D
A detox-pathway supplement with sound mechanism and almost no human outcome data.
Unclearmixed
ShatavariEvidence grade D
An Ayurvedic women's-health tonic with mostly traditional use and a lactation signal.
Unclearmixed
Dong QuaiEvidence grade D
A classic 'female tonic' whose menopause evidence is weak — and it interacts with blood thinners.
Unclearmixed

What is uncertain

Read off the same rows as above. Nothing here is added that the entry does not itself record.

Thin evidence: Black Cohosh (grade C); D-Mannose (grade C); DIM (Diindolylmethane) (grade C); Evening Primrose Oil (GLA) (grade C); Red Clover (grade C); Spearmint (grade C); Calcium D-Glucarate (grade D); Shatavari (grade D); Dong Quai (grade D).
Studies disagree: Vitex (Chasteberry) (mixed agreement); Cranberry (mixed agreement); Inositol (Myo-Inositol) (mixed agreement); Soy Isoflavones (mixed agreement); D-Chiro-Inositol (mixed agreement).

The evidence in words

The shortlist

Every compound in the knowledge base tagged to women's health, ordered by how strong its overall evidence is. Start at the top; the grade is the honest filter.

Worth considering first

Vitex (Chasteberry) (B) — One of the better-supported botanicals for PMS and cyclical breast pain, working through prolactin. · Cranberry (B) — Genuinely reduces recurrent UTIs via proanthocyanidins — prevention, not treatment. · Inositol (Myo-Inositol) (B) — A sugar-alcohol with genuinely good evidence in PCOS and reasonable anxiety/OCD signals. · Soy Isoflavones (B) — Phytoestrogens with real, modest evidence for menopausal hot flashes — and no, they don't feminize men. · D-Chiro-Inositol (B) — An inositol isomer for PCOS — best used in the physiological 40:1 ratio with myo-inositol, not alone at high doses.

Lower-evidence options

Black Cohosh (C) — A menopausal hot-flash botanical with genuinely divided trials and rare liver-safety signals. · D-Mannose (C) — A simple sugar that helps flush UTI-causing E. coli — promising early data for prevention. · DIM (Diindolylmethane) (C) — A cruciferous-vegetable metabolite that shifts estrogen metabolism — real biomarker effects, thin clinical data. · Evening Primrose Oil (GLA) (C) — A GLA source popular for PMS, breast pain, and eczema — mostly modest or null on rigorous review. · Red Clover (C) — Another isoflavone source for menopause with weaker, more inconsistent data than soy. · Spearmint (C) — A mint tea with a genuine anti-androgen signal for hirsutism/PCOS and early memory data. · Calcium D-Glucarate (D) — A detox-pathway supplement with sound mechanism and almost no human outcome data. · Shatavari (D) — An Ayurvedic women's-health tonic with mostly traditional use and a lactation signal. · Dong Quai (D) — A classic 'female tonic' whose menopause evidence is weak — and it interacts with blood thinners.

Goes with

Vitex (Chasteberry)Grade BEvidence grade B
CranberryGrade BEvidence grade B
Inositol (Myo-Inositol)Grade BEvidence grade B
Soy IsoflavonesGrade BEvidence grade B
D-Chiro-InositolGrade BEvidence grade B
Black CohoshGrade CEvidence grade C
D-MannoseGrade CEvidence grade C
DIM (Diindolylmethane)Grade CEvidence grade C

Entries that share this one's tags or conditions.

Black Cohosh for Menopausal hot flashesEvidence grade C — Divided trialsEvidence grade C
Black Cohosh for Menopause symptomsEvidence grade C — InconsistentEvidence grade C
Black Cohosh: dosage and how to take it~40 mg standardized daily.Evidence grade C
Black Cohosh: side effects, safety & interactionsRare hepatotoxicity reports — stop if any liver symptoms; avoid in liver disease.Evidence grade C

Sources

This entry lists no references of its own — it is assembled from the entries it links to, whose sources are on their pages.

Last revised Jul 10, 2026. A grade is this entry's reading of the evidence, not medical advice.