Compound or practice · Supplement
D-Mannose
A simple sugar that helps flush UTI-causing E. coli — promising early data for prevention.
- Overall grade
- Grade C
- Last revised
- 1
- graded outcome
- 0
- references listed
A structured monograph in Prometheus's bundled library. Its grades are the monograph's own reading of the evidence, not a peer-reviewed review.
2 at grade C — 2 graded rows
What is known
Each outcome with its grade (how strong the evidence is, A to D), the size of the effect where the entry records one, and how often studies agree.
- Recurrent UTI preventionEvidence grade C
Small trials
Moderatemixed
Conditions
How the entry reads its effect on diagnosed conditions: the direction first, then the grade. Never a substitute for the person who treats you.
- Recurrent urinary-tract infection May improveEvidence grade CPreventionGrade C
What is uncertain
Read off the same rows as above. Nothing here is added that the entry does not itself record.
- Thin evidence: Recurrent UTI prevention (grade C).
Interactions
Documented pairings with supplements and medicines. A medicine on this list is a conversation for whoever prescribes it.
CranberryWorks together
Complementary anti-adhesion — common pairing.
The evidence in words
What it is
D-mannose is a monosaccharide used to prevent and adjunctively manage E. coli urinary-tract infections.
How it works
It binds the adhesion molecules E. coli use to grip the bladder wall, letting them flush out in urine.
What the evidence shows
Small trials suggest D-mannose reduces recurrent UTIs comparably to low-dose antibiotics with fewer side effects; larger high-quality data are still limited. Not a substitute for treating an established infection.
How to use it
2 g/day for prevention; higher split doses in some protocols.
Safety & interactions
Well tolerated; caution in diabetes (it is a sugar, though minimally metabolized). Cranberry — Complementary anti-adhesion — common pairing.
Bottom line
A promising, low-side-effect UTI-prevention option, often with cranberry. Early but encouraging.
How it is used
As the entry records it, from the studies it summarises. Not a recommendation for you — doses that suit a trial population may not suit you.
- Standard
- 2 g/day for prevention.
Goes with
- CranberryComplementary anti-adhesion — common pairing.Evidence grade B
Related reading
Entries that share this one's tags or conditions.
- Cranberry for Active UTI treatmentEvidence grade D — Not a treatmentEvidence grade D
- Cranberry for Recurrent urinary-tract infectionEvidence grade B — PreventionEvidence grade B
- Cranberry for Recurrent UTI preventionEvidence grade B — In susceptible groupsEvidence grade B
- Cranberry: dosage and how to take it~36 mg proanthocyanidins/day.Evidence grade B
Sources
This entry lists no references of its own.
Last revised . A grade is this entry's reading of the evidence, not medical advice.