Compound or practice · Supplement
D-Chiro-Inositol
An inositol isomer for PCOS — best used in the physiological 40:1 ratio with myo-inositol, not alone at high doses.
- Overall grade
- Grade B
- Last revised
- 1
- graded outcome
- 0
- references listed
A structured monograph in Prometheus's bundled library. Its grades are the monograph's own reading of the evidence, not a peer-reviewed review.
1 at grade B — 1 graded row
What is known
Each outcome with its grade (how strong the evidence is, A to D), the size of the effect where the entry records one, and how often studies agree.
- PCOS (with myo-inositol)Evidence grade B
40:1 ratio
Moderatemixed
What is uncertain
Read off the same rows as above. Nothing here is added that the entry does not itself record.
- Studies disagree: PCOS (with myo-inositol) (mixed agreement).
Interactions
Documented pairings with supplements and medicines. A medicine on this list is a conversation for whoever prescribes it.
Inositol (Myo-Inositol)Works together
The 40:1 myo:D-chiro ratio is the evidence-based form.
The evidence in words
What it is
D-chiro-inositol is an insulin-signaling isomer of inositol used in PCOS and metabolic contexts.
How it works
It participates in insulin's downstream signaling; the body normally keeps a high myo-to-D-chiro ratio, and disrupting that can backfire.
What the evidence shows
Evidence supports inositol therapy in PCOS (ovulation, insulin sensitivity), but the best results use myo-inositol plus D-chiro in the ~40:1 physiological ratio; high-dose D-chiro alone can worsen egg quality. Context and ratio matter.
Safety & interactions
Generally safe; ratio matters more than dose. Inositol (Myo-Inositol) — The 40:1 myo:D-chiro ratio is the evidence-based form.
Bottom line
Useful for PCOS as part of the 40:1 myo:D-chiro ratio — not as a high-dose standalone. Pair it correctly.
Goes with
- Inositol (Myo-Inositol)The 40:1 myo:D-chiro ratio is the evidence-based form.Evidence grade B
Related reading
Entries that share this one's tags or conditions.
- D-Chiro-Inositol for PCOS (with myo-inositol)Evidence grade B — 40:1 ratioEvidence grade B
- D-Chiro-Inositol: side effects, safety & interactionsGenerally safe; ratio matters more than dose.Evidence grade B
- Inositol (Myo-Inositol) for PCOSEvidence grade B — Metabolic + ovulatoryEvidence grade B
- Inositol (Myo-Inositol) for AnxietyEvidence grade C — High dosesEvidence grade C
Sources
This entry lists no references of its own.
Last revised . A grade is this entry's reading of the evidence, not medical advice.