Compound or practice · Supplement
DIM (Diindolylmethane)
A cruciferous-vegetable metabolite that shifts estrogen metabolism — real biomarker effects, thin clinical data.
- Overall grade
- Grade C
- Last revised
- 2
- graded outcomes
- 0
- references listed
A structured monograph in Prometheus's bundled library. Its grades are the monograph's own reading of the evidence, not a peer-reviewed review.
1 at grade B · 1 at grade C — 2 graded rows
What is known
Each outcome with its grade (how strong the evidence is, A to D), the size of the effect where the entry records one, and how often studies agree.
- Estrogen-metabolite ratioEvidence grade B
Reliable biomarker shift
Moderatehigh
- Hormonal acne / lesionsEvidence grade C
Preliminary
Smalllow
What is uncertain
Read off the same rows as above. Nothing here is added that the entry does not itself record.
- Thin evidence: Hormonal acne / lesions (grade C).
Interactions
Documented pairings with supplements and medicines. A medicine on this list is a conversation for whoever prescribes it.
Calcium D-GlucarateWorks together
Both support estrogen clearance pathways.
The evidence in words
What it is
DIM forms from indole-3-carbinol in cruciferous vegetables and is used for estrogen balance and skin.
How it works
It shifts estrogen metabolism toward less-potent metabolites and modulates androgen and detox pathways.
What the evidence shows
It reliably changes urinary estrogen-metabolite ratios and has preliminary data in cervical/prostate lesions and hormonal acne; robust clinical outcomes are limited. Mechanistically interesting, clinically early.
How to use it
100–200 mg/day.
Safety & interactions
Generally tolerated; can alter drug metabolism and hormone levels. Calcium D-Glucarate — Both support estrogen clearance pathways.
Bottom line
A real estrogen-metabolism modulator with thin clinical proof. Reasonable to trial for hormonal skin/balance goals.
How it is used
As the entry records it, from the studies it summarises. Not a recommendation for you — doses that suit a trial population may not suit you.
- Standard
- 100–200 mg/day.
Goes with
- Calcium D-GlucarateBoth support estrogen clearance pathways.Evidence grade D
Related reading
Entries that share this one's tags or conditions.
- DIM (Diindolylmethane) for Estrogen-metabolite ratioEvidence grade B — Reliable biomarker shiftEvidence grade B
- DIM (Diindolylmethane) for Hormonal acne / lesionsEvidence grade C — PreliminaryEvidence grade C
- DIM (Diindolylmethane): dosage and how to take it100–200 mg/day.Evidence grade C
- DIM (Diindolylmethane): side effects, safety & interactionsGenerally tolerated; can alter drug metabolism and hormone levels.Evidence grade C
Sources
This entry lists no references of its own.
Last revised . A grade is this entry's reading of the evidence, not medical advice.