Compound or practice · Supplement
Calcium D-Glucarate
A detox-pathway supplement with sound mechanism and almost no human outcome data.
- Overall grade
- Grade D
- Last revised
- 1
- graded outcome
- 0
- references listed
A structured monograph in Prometheus's bundled library. Its grades are the monograph's own reading of the evidence, not a peer-reviewed review.
1 at grade D — 1 graded row
What is known
Each outcome with its grade (how strong the evidence is, A to D), the size of the effect where the entry records one, and how often studies agree.
- Estrogen / toxin clearanceEvidence grade D
Mechanistic only
Unclearlow
What is uncertain
Read off the same rows as above. Nothing here is added that the entry does not itself record.
- Thin evidence: Estrogen / toxin clearance (grade D).
Interactions
Documented pairings with supplements and medicines. A medicine on this list is a conversation for whoever prescribes it.
DIM (Diindolylmethane)Works together
Complementary estrogen-clearance mechanisms.
The evidence in words
What it is
Calcium D-glucarate supports the glucuronidation detox pathway, marketed for estrogen and toxin clearance.
How it works
It inhibits beta-glucuronidase, reducing the reabsorption of glucuronidated estrogens and toxins so they are excreted.
What the evidence shows
The mechanism is well-characterized in the lab and in animals, but human clinical-outcome data are essentially absent. Plausible, unproven.
How to use it
500–1,500 mg/day if trialing.
Safety & interactions
Appears safe; may accelerate clearance of glucuronidated drugs. DIM (Diindolylmethane) — Complementary estrogen-clearance mechanisms.
Bottom line
Good mechanism, no human outcomes. A speculative addition to estrogen-clearance stacks.
How it is used
As the entry records it, from the studies it summarises. Not a recommendation for you — doses that suit a trial population may not suit you.
- If trialing
- 500–1,500 mg/day.
Goes with
- DIM (Diindolylmethane)Complementary estrogen-clearance mechanisms.Evidence grade C
Related reading
Entries that share this one's tags or conditions.
- Calcium D-Glucarate for Estrogen / toxin clearanceEvidence grade D — Mechanistic onlyEvidence grade D
- Calcium D-Glucarate: dosage and how to take it500–1,500 mg/day.Evidence grade D
- Calcium D-Glucarate: side effects, safety & interactionsAppears safe; may accelerate clearance of glucuronidated drugs.Evidence grade D
- DIM (Diindolylmethane) for Estrogen-metabolite ratioEvidence grade B — Reliable biomarker shiftEvidence grade B
Sources
This entry lists no references of its own.
Last revised . A grade is this entry's reading of the evidence, not medical advice.