DIM (Diindolylmethane) for Hormonal acne / lesions

Evidence grade C — Preliminary

Overall grade: Grade C
Last revised: Jul 10, 2026; 1
graded outcome: 0
references listed

Assembled by the app from other entries in this library. It adds no evidence of its own — follow the links to the entries it draws on.

1 at grade C — 1 graded row

What is known

Each outcome with its grade (how strong the evidence is, A to D), the size of the effect where the entry records one, and how often studies agree.

Outcome	Grade	Effect size	Agreement
Hormonal acne / lesionsPreliminary	Evidence grade C	Small	low

Hormonal acne / lesionsEvidence grade C
Preliminary
Smalllow

What is uncertain

Read off the same rows as above. Nothing here is added that the entry does not itself record.

Thin evidence: Hormonal acne / lesions (grade C).

The evidence in words

The verdict

For hormonal acne / lesions, DIM (Diindolylmethane) earns evidence grade C (small effect, low consistency) — the evidence is limited or mixed. Preliminary

How it might work

It shifts estrogen metabolism toward less-potent metabolites and modulates androgen and detox pathways.

How to use it

100–200 mg/day.

Safety & cautions

Generally tolerated; can alter drug metabolism and hormone levels.

Bottom line

A real estrogen-metabolism modulator with thin clinical proof. Reasonable to trial for hormonal skin/balance goals.

How it is used

As the entry records it, from the studies it summarises. Not a recommendation for you — doses that suit a trial population may not suit you.

Standard: 100–200 mg/day.

Goes with

DIM (Diindolylmethane)Read the full DIM (Diindolylmethane) monographEvidence grade C

Entries that share this one's tags or conditions.

DIM (Diindolylmethane) for Estrogen-metabolite ratioEvidence grade B — Reliable biomarker shiftEvidence grade B
Calcium D-Glucarate for Estrogen / toxin clearanceEvidence grade D — Mechanistic onlyEvidence grade D
DIM (Diindolylmethane): dosage and how to take it100–200 mg/day.Evidence grade C
DIM (Diindolylmethane): side effects, safety & interactionsGenerally tolerated; can alter drug metabolism and hormone levels.Evidence grade C

Sources

This entry lists no references of its own — it is assembled from the entries it links to, whose sources are on their pages.

Last revised Jul 10, 2026. A grade is this entry's reading of the evidence, not medical advice.