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Goal guide · Supplement

Supplements for anxiety

11 compounds relevant to anxiety, ranked by overall evidence grade.

Overall grade
Grade B
Last revised
11
graded outcomes
0
references listed
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Assembled by the app from other entries in this library. It adds no evidence of its own — follow the links to the entries it draws on.

5 at grade B · 5 at grade C · 1 at grade D — 11 graded rows

What is known

Each outcome with its grade (how strong the evidence is, A to D), the size of the effect where the entry records one, and how often studies agree.

  • SaffronEvidence grade B

    Surprisingly solid for low mood at ~30 mg/day — a rare botantical antidepressant with real trials, carrying the serotonergic caveat.

    Unclearmixed

  • Inositol (Myo-Inositol)Evidence grade B

    A sugar-alcohol with genuinely good evidence in PCOS and reasonable anxiety/OCD signals.

    Unclearmixed

  • KavaEvidence grade B

    One of the few genuinely effective anxiety botanicals — shadowed by a real (if debated) liver-safety history.

    Unclearmixed

  • Lavender (Silexan)Evidence grade B

    Oral lavender oil (Silexan) has genuinely good anxiety evidence — rivaling low-dose anxiolytics without sedation.

    Unclearmixed

  • CBD (Cannabidiol)Evidence grade B

    A non-intoxicating cannabinoid with rock-solid epilepsy evidence and promising-but-unsettled anxiety and sleep data.

    Unclearmixed

  • Holy Basil (Tulsi)Evidence grade C

    A gentle adaptogen with early evidence for stress, anxiety, and metabolic markers — promising, thin, low-risk.

    Unclearmixed

  • PassionflowerEvidence grade C

    A gentle GABAergic herb with modest anxiety and sleep signals — a mild, benign calmer.

    Unclearmixed

  • Lemon BalmEvidence grade C

    A pleasant mint-family herb with small acute anxiety, mood, and sleep signals.

    Unclearmixed

  • Kanna (Sceletium tortuosum)Evidence grade C

    A South African mood herb (standardized as Zembrin) with early anxiolytic and cognitive signals — and serotonergic caution.

    Unclearmixed

  • Ziziphus (Jujube / Suanzaoren)Evidence grade C

    A traditional jujube-seed sedative used across Asia for insomnia and anxiety — plausible and gentle, lightly studied.

    Unclearmixed

  • AniracetamEvidence grade D

    A fat-soluble racetam with an anxiety-and-mood reputation and mostly preclinical human backing.

    Unclearmixed

What is uncertain

Read off the same rows as above. Nothing here is added that the entry does not itself record.

  • Thin evidence: Holy Basil (Tulsi) (grade C); Passionflower (grade C); Lemon Balm (grade C); Kanna (Sceletium tortuosum) (grade C); Ziziphus (Jujube / Suanzaoren) (grade C); Aniracetam (grade D).
  • Studies disagree: Saffron (mixed agreement); Inositol (Myo-Inositol) (mixed agreement); Kava (mixed agreement); Lavender (Silexan) (mixed agreement); CBD (Cannabidiol) (mixed agreement).

The evidence in words

The shortlist

Every compound in the knowledge base tagged to anxiety, ordered by how strong its overall evidence is. Start at the top; the grade is the honest filter.

Worth considering first

Saffron (B) — Surprisingly solid for low mood at ~30 mg/day — a rare botantical antidepressant with real trials, carrying the serotonergic caveat. · Inositol (Myo-Inositol) (B) — A sugar-alcohol with genuinely good evidence in PCOS and reasonable anxiety/OCD signals. · Kava (B) — One of the few genuinely effective anxiety botanicals — shadowed by a real (if debated) liver-safety history. · Lavender (Silexan) (B) — Oral lavender oil (Silexan) has genuinely good anxiety evidence — rivaling low-dose anxiolytics without sedation. · CBD (Cannabidiol) (B) — A non-intoxicating cannabinoid with rock-solid epilepsy evidence and promising-but-unsettled anxiety and sleep data.

Lower-evidence options

Holy Basil (Tulsi) (C) — A gentle adaptogen with early evidence for stress, anxiety, and metabolic markers — promising, thin, low-risk. · Passionflower (C) — A gentle GABAergic herb with modest anxiety and sleep signals — a mild, benign calmer. · Lemon Balm (C) — A pleasant mint-family herb with small acute anxiety, mood, and sleep signals. · Kanna (Sceletium tortuosum) (C) — A South African mood herb (standardized as Zembrin) with early anxiolytic and cognitive signals — and serotonergic caution. · Ziziphus (Jujube / Suanzaoren) (C) — A traditional jujube-seed sedative used across Asia for insomnia and anxiety — plausible and gentle, lightly studied. · Aniracetam (D) — A fat-soluble racetam with an anxiety-and-mood reputation and mostly preclinical human backing.

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Related reading

Entries that share this one's tags or conditions.

Sources

This entry lists no references of its own — it is assembled from the entries it links to, whose sources are on their pages.

Last revised . A grade is this entry's reading of the evidence, not medical advice.