Safety · Supplement
Valerian: side effects, safety & interactions
Generally safe; additive sedation with alcohol, benzodiazepines, and other CNS depressants.
- Overall grade
- Grade C
- Last revised
- 0
- graded outcomes
- 0
- references listed
Assembled by the app from other entries in this library. It adds no evidence of its own — follow the links to the entries it draws on.
What is uncertain
Read off the same rows as above. Nothing here is added that the entry does not itself record.
- Watch with Melatonin: Two sedating levers — pick one to avoid morning grog.
The evidence in words
Safety profile
Generally safe; additive sedation with alcohol, benzodiazepines, and other CNS depressants.
Interactions to respect
Melatonin — Two sedating levers — pick one to avoid morning grog.
What Valerian is
Valerian root is a long-used sleep herb thought to act on GABA signaling.
The honest bottom line
Hit-or-miss. Worth a cheap trial for mild insomnia, but don't stack it with other sedatives and expect some morning fog.
Related reading
Entries that share this one's tags or conditions.
- ValerianA traditional sedative herb with inconsistent trials and a common morning-grogginess complaint.Evidence grade C
- Apigenin: side effects, safety & interactionsBenign at these doses; theoretical mild CYP interactions at high intakes.Evidence grade C
- Glycine: side effects, safety & interactionsVery safe and well tolerated at these doses.Evidence grade B
- L-Tryptophan / 5-HTP: side effects, safety & interactionsThe serotonergic-drug interaction is the headline risk. Historical contamination concerns with tryptophan underscore buyEvidence grade C
Sources
This entry lists no references of its own — it is assembled from the entries it links to, whose sources are on their pages.
Last revised . A grade is this entry's reading of the evidence, not medical advice.