Safety · Supplement
Glycine: side effects, safety & interactions
Very safe and well tolerated at these doses.
- Overall grade
- Grade B
- Last revised
- 0
- graded outcomes
- 0
- references listed
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What is uncertain
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- Watch with Melatonin: Both pre-bed and compatible — glycine 60–90 min out, melatonin ~30.
The evidence in words
Safety profile
Very safe and well tolerated at these doses.
Interactions to respect
Melatonin — Both pre-bed and compatible — glycine 60–90 min out, melatonin ~30.
What Glycine is
Glycine is the simplest amino acid, an inhibitory neurotransmitter, and a building block of collagen and glutathione. It is sweet-tasting and inexpensive.
The honest bottom line
An underrated, cheap sleep-onset aid: 3 g before bed. Doubles as a collagen and glutathione building block.
Related reading
Entries that share this one's tags or conditions.
- Apigenin: side effects, safety & interactionsBenign at these doses; theoretical mild CYP interactions at high intakes.Evidence grade C
- GlycineA cheap amino acid that lowers core temperature for easier sleep onset and supports collagen and glutathione.Evidence grade B
- Glycine for Next-day alertnessEvidence grade C — After better sleepEvidence grade C
- Glycine for Sleep onset / qualityEvidence grade B — 3 g pre-bedEvidence grade B
Sources
This entry lists no references of its own — it is assembled from the entries it links to, whose sources are on their pages.
Last revised . A grade is this entry's reading of the evidence, not medical advice.