Safety · Supplement
Synephrine: side effects, safety & interactions
Raises heart rate/blood pressure; caution with stimulants, heart conditions, and before exercise.
- Overall grade
- Grade C
- Last revised
- 0
- graded outcomes
- 0
- references listed
Assembled by the app from other entries in this library. It adds no evidence of its own — follow the links to the entries it draws on.
What is uncertain
Read off the same rows as above. Nothing here is added that the entry does not itself record.
- Watch with Caffeine: Additive cardiovascular stimulation in fat-burner stacks.
The evidence in words
Safety profile
Raises heart rate/blood pressure; caution with stimulants, heart conditions, and before exercise.
Interactions to respect
Caffeine — Additive cardiovascular stimulation in fat-burner stacks.
What Synephrine is
Synephrine is a stimulant alkaloid from bitter orange (Citrus aurantium), common in fat-burner formulas.
The honest bottom line
A mild thermogenic with a real stimulant footprint. Modest at best; treat stacked fat-burners with caution.
Related reading
Entries that share this one's tags or conditions.
- Capsaicin / Capsimax: side effects, safety & interactionsGI burning at high oral doses; topical can sting. Beadlet forms reduce oral discomfort.Evidence grade C
- Yohimbine: side effects, safety & interactionsAnxiogenic, raises heart rate and blood pressure; risky with anxiety disorders, hypertension, and MAOIs/stimulants.Evidence grade C
- Caffeine: side effects, safety & interactionsSafe for most in moderation; excess causes anxiety, palpitations, and insomnia. Dependence and withdrawal (headache, fatEvidence grade A
- CLA (Conjugated Linoleic Acid): side effects, safety & interactionsHigh-dose synthetic CLA may adversely affect metabolic markers.Evidence grade D
Sources
This entry lists no references of its own — it is assembled from the entries it links to, whose sources are on their pages.
Last revised . A grade is this entry's reading of the evidence, not medical advice.