Safety · Supplement
Sarcosine: side effects, safety & interactions
Generally well tolerated; should not replace prescribed treatment, and NMDA modulation warrants clinical oversight in ps
- Overall grade
- Grade C
- Last revised
- 0
- graded outcomes
- 0
- references listed
Assembled by the app from other entries in this library. It adds no evidence of its own — follow the links to the entries it draws on.
The evidence in words
Safety profile
Generally well tolerated; should not replace prescribed treatment, and NMDA modulation warrants clinical oversight in psychiatric illness.
Interactions to respect
No major interactions are on record for Sarcosine at typical doses, but tell your clinician about everything you take.
What Sarcosine is
Sarcosine (N-methylglycine) is a glycine derivative that enhances NMDA-receptor signaling, studied mainly as a psychiatric adjunct.
The honest bottom line
A mechanistically interesting NMDA-enhancing amino acid with real (if small) adjunct evidence in schizophrenia — a clinical adjunct, not a casual nootropic.
Related reading
Entries that share this one's tags or conditions.
- Acetyl-L-Carnitine (ALCAR): side effects, safety & interactionsGenerally safe; can cause GI upset, and, like carnitine, may raise TMAO. Mildly stimulating for some — take earlier in tEvidence grade B
- Kanna (Sceletium tortuosum): side effects, safety & interactionsGenerally tolerated (mild headache, GI); being serotonergic, do not combine with SSRIs/SNRIs/MAOIs — serotonin-syndrome Evidence grade C
- SarcosineAn NMDA co-agonist amino acid with real add-on evidence in schizophrenia — a niche, mechanism-driven mood/cognition agent.Evidence grade C
- Sarcosine for OCD / depressionEvidence grade C — PreliminaryEvidence grade C
Sources
This entry lists no references of its own — it is assembled from the entries it links to, whose sources are on their pages.
Last revised . A grade is this entry's reading of the evidence, not medical advice.