Safety · Supplement

Kanna (Sceletium tortuosum): side effects, safety & interactions

Generally tolerated (mild headache, GI); being serotonergic, do not combine with SSRIs/SNRIs/MAOIs — serotonin-syndrome

Assembled by the app from other entries in this library. It adds no evidence of its own — follow the links to the entries it draws on.

The evidence in words

Generally tolerated (mild headache, GI); being serotonergic, do not combine with SSRIs/SNRIs/MAOIs — serotonin-syndrome risk.

SSRIs / SNRIs — SSRI-like reuptake inhibition — serotonin-syndrome risk; don't combine.

Kanna is a succulent traditionally chewed for mood; the standardized extract Zembrin is used for stress and cognition.

A promising mood-and-focus herb with a real dual mechanism — but treat it like a serotonergic agent and never stack it with antidepressants.

Entries that share this one's tags or conditions.

Saffron: side effects, safety & interactionsWell tolerated at supplemental doses; culinary-scale amounts are safe, but very high doses are toxic. As a serotonergic Evidence grade B
Acetyl-L-Carnitine (ALCAR): side effects, safety & interactionsGenerally safe; can cause GI upset, and, like carnitine, may raise TMAO. Mildly stimulating for some — take earlier in tEvidence grade B
Kanna (Sceletium tortuosum)A South African mood herb (standardized as Zembrin) with early anxiolytic and cognitive signals — and serotonergic caution.Evidence grade C
Kanna (Sceletium tortuosum) for Anxiety / moodEvidence grade C — Zembrin extractEvidence grade C

This entry lists no references of its own — it is assembled from the entries it links to, whose sources are on their pages.

Last revised Jul 10, 2026. A grade is this entry's reading of the evidence, not medical advice.