Evidence brief · Supplement
Kanna (Sceletium tortuosum) for Anxiety / mood
Evidence grade C — Zembrin extract
- Overall grade
- Grade C
- Last revised
- 1
- graded outcome
- 0
- references listed
Assembled by the app from other entries in this library. It adds no evidence of its own — follow the links to the entries it draws on.
1 at grade C — 1 graded row
What is known
Each outcome with its grade (how strong the evidence is, A to D), the size of the effect where the entry records one, and how often studies agree.
- Anxiety / moodEvidence grade C
Zembrin extract
Smallmixed
What is uncertain
Read off the same rows as above. Nothing here is added that the entry does not itself record.
- Thin evidence: Anxiety / mood (grade C).
The evidence in words
The verdict
For anxiety / mood, Kanna (Sceletium tortuosum) earns evidence grade C (small effect, mixed consistency) — the evidence is limited or mixed. Zembrin extract
How it might work
Its alkaloids (mesembrine) inhibit serotonin reuptake and PDE4, giving combined serotonergic and pro-cognitive effects.
How to use it
Safety & cautions
Generally tolerated (mild headache, GI); being serotonergic, do not combine with SSRIs/SNRIs/MAOIs — serotonin-syndrome risk.
Bottom line
A promising mood-and-focus herb with a real dual mechanism — but treat it like a serotonergic agent and never stack it with antidepressants.
Goes with
- Kanna (Sceletium tortuosum)Read the full Kanna (Sceletium tortuosum) monographEvidence grade C
Related reading
Entries that share this one's tags or conditions.
- Kanna (Sceletium tortuosum) for Cognition (executive)Evidence grade C — EarlyEvidence grade C
- Kanna (Sceletium tortuosum): side effects, safety & interactionsGenerally tolerated (mild headache, GI); being serotonergic, do not combine with SSRIs/SNRIs/MAOIs — serotonin-syndrome Evidence grade C
- Saffron for Anxiety / PMSEvidence grade C — Secondary signalsEvidence grade C
- Saffron for Depression (mild-moderate)Evidence grade B — Small but repeated trialsEvidence grade B
Sources
This entry lists no references of its own — it is assembled from the entries it links to, whose sources are on their pages.
Last revised . A grade is this entry's reading of the evidence, not medical advice.