Safety · Supplement
Rapamycin (Sirolimus): side effects, safety & interactions
Prescription-only for good reason: immunosuppression, mouth ulcers, impaired glucose tolerance, and lipid changes. Off-l
- Overall grade
- Grade B
- Last revised
- 0
- graded outcomes
- 0
- references listed
Assembled by the app from other entries in this library. It adds no evidence of its own — follow the links to the entries it draws on.
The evidence in words
Safety profile
Prescription-only for good reason: immunosuppression, mouth ulcers, impaired glucose tolerance, and lipid changes. Off-label longevity use should only happen under a knowledgeable physician.
Interactions to respect
Grapefruit — CYP3A4 inhibition raises rapamycin levels substantially.
What Rapamycin (Sirolimus) is
Rapamycin is an approved immunosuppressant (transplant, some cancers) being explored off-label at intermittent low doses for longevity.
The honest bottom line
The strongest lifespan-extending molecule known in animals, and a genuine frontier in human aging research — but a serious immunosuppressant drug, not a self-prescribed supplement.
Related reading
Entries that share this one's tags or conditions.
- Rapamycin (Sirolimus)A prescription mTOR inhibitor that extends lifespan in animals like nothing else — and the most serious off-label longevity experiment in humans.Evidence grade B
- Rapamycin (Sirolimus) for Human longevityEvidence grade D — No outcome data yetEvidence grade D
- Rapamycin (Sirolimus) for Lifespan (animals)Evidence grade A — Multiple speciesEvidence grade A
- Spermidine: side effects, safety & interactionsFood-derived, appears safe.Evidence grade C
Sources
This entry lists no references of its own — it is assembled from the entries it links to, whose sources are on their pages.
Last revised . A grade is this entry's reading of the evidence, not medical advice.