Evidence brief · Supplement
Rapamycin (Sirolimus) for Lifespan (animals)
Evidence grade A — Multiple species
- Overall grade
- Grade A
- Last revised
- 1
- graded outcome
- 0
- references listed
Assembled by the app from other entries in this library. It adds no evidence of its own — follow the links to the entries it draws on.
1 at grade A — 1 graded row
What is known
Each outcome with its grade (how strong the evidence is, A to D), the size of the effect where the entry records one, and how often studies agree.
- Lifespan (animals)Evidence grade A
Multiple species
Largehigh
The evidence in words
The verdict
For lifespan (animals), Rapamycin (Sirolimus) earns evidence grade A (large effect, high consistency) — there is real evidence here. Multiple species
How it might work
It inhibits mTOR, the growth-and-nutrient-sensing pathway; dialing mTOR down mimics aspects of caloric restriction and boosts autophagy.
How to use it
Safety & cautions
Prescription-only for good reason: immunosuppression, mouth ulcers, impaired glucose tolerance, and lipid changes. Off-label longevity use should only happen under a knowledgeable physician.
Bottom line
The strongest lifespan-extending molecule known in animals, and a genuine frontier in human aging research — but a serious immunosuppressant drug, not a self-prescribed supplement.
Goes with
- Rapamycin (Sirolimus)Read the full Rapamycin (Sirolimus) monographEvidence grade B
Related reading
Entries that share this one's tags or conditions.
- Rapamycin (Sirolimus) for Human longevityEvidence grade D — No outcome data yetEvidence grade D
- Rapamycin (Sirolimus): side effects, safety & interactionsPrescription-only for good reason: immunosuppression, mouth ulcers, impaired glucose tolerance, and lipid changes. Off-lEvidence grade B
- Spermidine for Memory (at-risk older adults)Evidence grade C — Early trialsEvidence grade C
- Spermidine for Mortality (observational)Evidence grade C — Association onlyEvidence grade C
Sources
This entry lists no references of its own — it is assembled from the entries it links to, whose sources are on their pages.
Last revised . A grade is this entry's reading of the evidence, not medical advice.