Evidence brief · Supplement
Spermidine for Mortality (observational)
Evidence grade C — Association only
- Overall grade
- Grade C
- Last revised
- 1
- graded outcome
- 0
- references listed
Assembled by the app from other entries in this library. It adds no evidence of its own — follow the links to the entries it draws on.
1 at grade C — 1 graded row
What is known
Each outcome with its grade (how strong the evidence is, A to D), the size of the effect where the entry records one, and how often studies agree.
- Mortality (observational)Evidence grade C
Association only
Unclearmixed
What is uncertain
Read off the same rows as above. Nothing here is added that the entry does not itself record.
- Thin evidence: Mortality (observational) (grade C).
The evidence in words
The verdict
For mortality (observational), Spermidine earns evidence grade C (unclear effect, mixed consistency) — the evidence is limited or mixed. Association only
How it might work
By promoting autophagy it may support cellular housekeeping linked to aging and cognition.
How to use it
1–6 mg/day from wheat-germ extract or supplements.
Safety & cautions
Food-derived, appears safe.
Bottom line
One of the more interesting longevity candidates on autophagy grounds, with early cognitive signals. Low-risk to trial; evidence is still building.
How it is used
As the entry records it, from the studies it summarises. Not a recommendation for you — doses that suit a trial population may not suit you.
- Standard
- 1–6 mg/day.
Goes with
- SpermidineRead the full Spermidine monographEvidence grade C
Related reading
Entries that share this one's tags or conditions.
- Spermidine for Memory (at-risk older adults)Evidence grade C — Early trialsEvidence grade C
- Spermidine: dosage and how to take it1–6 mg/day.Evidence grade C
- Spermidine: side effects, safety & interactionsFood-derived, appears safe.Evidence grade C
- Calcium AKG for Biological aging (humans)Evidence grade D — One small studyEvidence grade D
Sources
This entry lists no references of its own — it is assembled from the entries it links to, whose sources are on their pages.
Last revised . A grade is this entry's reading of the evidence, not medical advice.