Safety · Supplement
Spermidine: side effects, safety & interactions
Food-derived, appears safe.
- Overall grade
- Grade C
- Last revised
- 0
- graded outcomes
- 0
- references listed
Assembled by the app from other entries in this library. It adds no evidence of its own — follow the links to the entries it draws on.
The evidence in words
Safety profile
Food-derived, appears safe.
Interactions to respect
No major interactions are on record for Spermidine at typical doses, but tell your clinician about everything you take.
What Spermidine is
Spermidine is a polyamine found in wheat germ and fermented foods that induces autophagy, the cell's recycling process.
The honest bottom line
One of the more interesting longevity candidates on autophagy grounds, with early cognitive signals. Low-risk to trial; evidence is still building.
Related reading
Entries that share this one's tags or conditions.
- Calcium AKG: side effects, safety & interactionsAppears safe short-term; long-term unknown.Evidence grade D
- Cinnamon: side effects, safety & interactionsHigh-dose cassia coumarin can stress the liver; additive glucose lowering with diabetes drugs.Evidence grade C
- Cocoa Flavanols: side effects, safety & interactionsSafe; watch caffeine/theobromine and the sugar in chocolate.Evidence grade B
- Fisetin: side effects, safety & interactionsFood flavonoid, appears safe; human dosing unestablished.Evidence grade D
Sources
This entry lists no references of its own — it is assembled from the entries it links to, whose sources are on their pages.
Last revised . A grade is this entry's reading of the evidence, not medical advice.