Safety · Supplement
L-Arginine: side effects, safety & interactions
GI upset at higher doses; additive blood-pressure lowering; caution with erectile-dysfunction drugs.
- Overall grade
- Grade C
- Last revised
- 0
- graded outcomes
- 0
- references listed
Assembled by the app from other entries in this library. It adds no evidence of its own — follow the links to the entries it draws on.
The evidence in words
Safety profile
GI upset at higher doses; additive blood-pressure lowering; caution with erectile-dysfunction drugs.
Interactions to respect
Blood-pressure medications — Additive blood-pressure lowering.
What L-Arginine is
L-arginine is a conditionally-essential amino acid and nitric-oxide precursor sold for pumps, blood pressure, and erectile function.
The honest bottom line
Outclassed by citrulline for pumps and endurance. Modest for blood pressure and erectile function; the gut is the bottleneck.
Related reading
Entries that share this one's tags or conditions.
- L-Arginine for Blood pressureEvidence grade C — Modest reductionEvidence grade C
- L-Citrulline: side effects, safety & interactionsVery well tolerated, with far less GI upset than arginine. Its blood-pressure lowering is additive with antihypertensiveEvidence grade B
- Beetroot / Dietary Nitrate: side effects, safety & interactionsSafe; harmless pink urine/stool. Additive blood-pressure lowering with antihypertensives.Evidence grade B
- L-ArginineThe direct nitric-oxide precursor that mostly loses to citrulline because the gut destroys it first.Evidence grade C
Sources
This entry lists no references of its own — it is assembled from the entries it links to, whose sources are on their pages.
Last revised . A grade is this entry's reading of the evidence, not medical advice.