Safety · Supplement
L-Citrulline: side effects, safety & interactions
Very well tolerated, with far less GI upset than arginine. Its blood-pressure lowering is additive with antihypertensive
- Overall grade
- Grade B
- Last revised
- 0
- graded outcomes
- 0
- references listed
Assembled by the app from other entries in this library. It adds no evidence of its own — follow the links to the entries it draws on.
The evidence in words
Safety profile
Very well tolerated, with far less GI upset than arginine. Its blood-pressure lowering is additive with antihypertensive drugs.
Interactions to respect
Blood-pressure medications — Additive blood-pressure lowering — cuff it if on BP meds.
What L-Citrulline is
L-citrulline is a non-essential amino acid that the body converts to arginine and then nitric oxide more effectively than arginine taken directly, which is largely destroyed in the gut. It is sold as pure citrulline or as citrulline malate.
The honest bottom line
One of the few pre-workout ingredients with real, if modest, support. 6–8 g an hour before lifting for reps and pump; also a mild blood-pressure helper.
Related reading
Entries that share this one's tags or conditions.
- L-Arginine: side effects, safety & interactionsGI upset at higher doses; additive blood-pressure lowering; caution with erectile-dysfunction drugs.Evidence grade C
- L-Citrulline for Blood pressureEvidence grade B — Modest reductionEvidence grade B
- Agmatine: side effects, safety & interactionsLimited human safety data; generally tolerated short-term.Evidence grade D
- Beetroot / Dietary Nitrate: side effects, safety & interactionsSafe; harmless pink urine/stool. Additive blood-pressure lowering with antihypertensives.Evidence grade B
Sources
This entry lists no references of its own — it is assembled from the entries it links to, whose sources are on their pages.
Last revised . A grade is this entry's reading of the evidence, not medical advice.