Evidence brief · Supplement
L-Arginine for Blood pressure
Evidence grade C — Modest reduction
- Overall grade
- Grade C
- Last revised
- 1
- graded outcome
- 0
- references listed
Assembled by the app from other entries in this library. It adds no evidence of its own — follow the links to the entries it draws on.
1 at grade C — 1 graded row
What is known
Each outcome with its grade (how strong the evidence is, A to D), the size of the effect where the entry records one, and how often studies agree.
- Blood pressureEvidence grade C
Modest reduction
Smallmixed
What is uncertain
Read off the same rows as above. Nothing here is added that the entry does not itself record.
- Thin evidence: Blood pressure (grade C).
The evidence in words
The verdict
For blood pressure, L-Arginine earns evidence grade C (small effect, mixed consistency) — the evidence is limited or mixed. Modest reduction
How it might work
It is a substrate for nitric-oxide synthase, promoting vasodilation — but first-pass gut and liver metabolism blunts oral absorption badly.
How to use it
3–6 g if used; citrulline is usually preferable for the same goals.
Safety & cautions
GI upset at higher doses; additive blood-pressure lowering; caution with erectile-dysfunction drugs.
Bottom line
Outclassed by citrulline for pumps and endurance. Modest for blood pressure and erectile function; the gut is the bottleneck.
How it is used
As the entry records it, from the studies it summarises. Not a recommendation for you — doses that suit a trial population may not suit you.
- Standard
- 3–6 g; citrulline usually preferable.
Goes with
- L-ArginineRead the full L-Arginine monographEvidence grade C
Related reading
Entries that share this one's tags or conditions.
- L-Arginine for Erectile dysfunctionEvidence grade C — High-dose or combinedEvidence grade C
- L-Arginine for Erectile functionEvidence grade C — Higher doses / combinedEvidence grade C
- L-Arginine for Exercise pump / performanceEvidence grade D — Poor oral absorptionEvidence grade D
- L-Citrulline for Blood pressureEvidence grade B — Modest reductionEvidence grade B
Sources
This entry lists no references of its own — it is assembled from the entries it links to, whose sources are on their pages.
Last revised . A grade is this entry's reading of the evidence, not medical advice.