Medication · Medication
PPIs
Proton-pump inhibitors — powerful stomach-acid reducers for reflux and ulcers.
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A medication reference built from the interaction graph. It is not prescribing information — the label and your prescriber are.
What is uncertain
Read off the same rows as above. Nothing here is added that the entry does not itself record.
- Caution with Betaine HCl: Directly opposes acid-suppressing drugs — don't combine.
Interactions
Documented pairings with supplements and medicines. A medicine on this list is a conversation for whoever prescribes it.
Betaine HClCaution
Directly opposes acid-suppressing drugs — don't combine.
Vitamin B12Depletes a nutrient
Acid suppression starves the absorption pathway over years.
MagnesiumDepletes a nutrient
Prolonged PPI use can drive magnesium clinically low.
IronDepletes a nutrient
Low stomach acid from PPIs reduces non-heme iron absorption over time.
CalciumMind the timing
Calcium carbonate needs stomach acid — take citrate, or separate from acid-suppressing drugs.
The evidence in words
What it is
Proton-pump inhibitors — powerful stomach-acid reducers for reflux and ulcers.
How it works
They shut down acid production; years of low acid impair the absorption of nutrients that need it.
What it's used for
GERD, peptic ulcers, H. pylori regimens.
Supplement & drug interactions
PPIs has 5 documented interactions mapped below and in the interactions graph. Long-term PPIs deplete vitamin B12 and magnesium (the FDA-labeled one) and reduce non-heme iron and calcium-carbonate absorption. On chronic PPIs, monitor B12 and magnesium and prefer citrate mineral forms.
Nutrient depletions
Drug-induced nutrient depletion is real and under-recognized: PPIs can lower Vitamin B12, Magnesium, Iron. Acid suppression starves the absorption pathway over years. Prolonged PPI use can drive magnesium clinically low. Low stomach acid from PPIs reduces non-heme iron absorption over time.
The rule
This is a medication reference for spotting interactions, not dosing advice. Every change to a supplement stack around a prescription belongs with the person who prescribes it.
Related reading
Entries that share this one's tags or conditions.
- CorticosteroidsPotent anti-inflammatory and immunosuppressant steroids.Evidence grade A
- Diuretics'Water pills' that increase fluid and electrolyte excretion.Evidence grade A
- Magnesium + Diuretics: one depletes the otherLoop and thiazide diuretics waste magnesium — a common cause of low levels.Evidence grade B
- Magnesium + PPIs: one depletes the otherProlonged PPI use can drive magnesium clinically low.Evidence grade B
Sources
This entry lists no references of its own.
Last revised . A grade is this entry's reading of the evidence, not medical advice.