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Goal guide · Supplement

Supplements for skin & connective tissue

13 compounds relevant to skin & connective tissue, ranked by overall evidence grade.

Overall grade
Grade B
Last revised
13
graded outcomes
0
references listed
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Assembled by the app from other entries in this library. It adds no evidence of its own — follow the links to the entries it draws on.

2 at grade B · 10 at grade C · 1 at grade D — 13 graded rows

What is known

Each outcome with its grade (how strong the evidence is, A to D), the size of the effect where the entry records one, and how often studies agree.

  • Niacin (B3)Evidence grade B

    Corrects pellagra, powerfully shifts blood lipids — but as a heart drug it failed to cut events and added harm.

    Unclearmixed

  • Collagen PeptidesEvidence grade B

    Real, if modest, evidence for tendon, joint, and skin outcomes when taken with vitamin C before loading — better than its hype suggested a decade ago.

    Unclearmixed

  • Gotu KolaEvidence grade C

    A traditional 'brain and skin' herb with modest wound-healing and vein data, weaker cognitive evidence.

    Unclearmixed

  • DIM (Diindolylmethane)Evidence grade C

    A cruciferous-vegetable metabolite that shifts estrogen metabolism — real biomarker effects, thin clinical data.

    Unclearmixed

  • Evening Primrose Oil (GLA)Evidence grade C

    A GLA source popular for PMS, breast pain, and eczema — mostly modest or null on rigorous review.

    Unclearmixed

  • Biotin (B7)Evidence grade C

    The hair-and-nails vitamin that only helps if you're deficient — and wrecks common lab tests at high doses.

    Unclearmixed

  • SiliconEvidence grade C

    A trace element with modest bone and hair/skin/nail signals via collagen support.

    Unclearmixed

  • AstaxanthinEvidence grade C

    A potent carotenoid antioxidant with modest skin-photoprotection and exercise-recovery signals.

    Unclearmixed

  • Hyaluronic Acid (Oral)Evidence grade C

    An oral skin-and-joint supplement with modest hydration and knee-comfort signals.

    Unclearmixed

  • Aloe VeraEvidence grade C

    Topical aloe helps minor burns; oral aloe has modest glucose and IBS signals but a laxative/safety caveat.

    Unclearmixed

  • Pycnogenol (Pine Bark)Evidence grade C

    A pine-bark polyphenol with broad small-trial signals for circulation, blood pressure, and skin — much of it single-source.

    Unclearmixed

  • Sea BuckthornEvidence grade C

    An omega-7-rich berry oil with genuine dry-eye and skin-barrier signals.

    Unclearmixed

  • DMAEEvidence grade D

    A choline-adjacent compound for focus and skin with weak, mixed evidence.

    Unclearmixed

What is uncertain

Read off the same rows as above. Nothing here is added that the entry does not itself record.

  • Thin evidence: Gotu Kola (grade C); DIM (Diindolylmethane) (grade C); Evening Primrose Oil (GLA) (grade C); Biotin (B7) (grade C); Silicon (grade C); Astaxanthin (grade C); Hyaluronic Acid (Oral) (grade C); Aloe Vera (grade C); Pycnogenol (Pine Bark) (grade C); Sea Buckthorn (grade C); DMAE (grade D).
  • Studies disagree: Niacin (B3) (mixed agreement); Collagen Peptides (mixed agreement).

The evidence in words

The shortlist

Every compound in the knowledge base tagged to skin & connective tissue, ordered by how strong its overall evidence is. Start at the top; the grade is the honest filter.

Worth considering first

Niacin (B3) (B) — Corrects pellagra, powerfully shifts blood lipids — but as a heart drug it failed to cut events and added harm. · Collagen Peptides (B) — Real, if modest, evidence for tendon, joint, and skin outcomes when taken with vitamin C before loading — better than its hype suggested a decade ago.

Lower-evidence options

Gotu Kola (C) — A traditional 'brain and skin' herb with modest wound-healing and vein data, weaker cognitive evidence. · DIM (Diindolylmethane) (C) — A cruciferous-vegetable metabolite that shifts estrogen metabolism — real biomarker effects, thin clinical data. · Evening Primrose Oil (GLA) (C) — A GLA source popular for PMS, breast pain, and eczema — mostly modest or null on rigorous review. · Biotin (B7) (C) — The hair-and-nails vitamin that only helps if you're deficient — and wrecks common lab tests at high doses. · Silicon (C) — A trace element with modest bone and hair/skin/nail signals via collagen support. · Astaxanthin (C) — A potent carotenoid antioxidant with modest skin-photoprotection and exercise-recovery signals. · Hyaluronic Acid (Oral) (C) — An oral skin-and-joint supplement with modest hydration and knee-comfort signals. · Aloe Vera (C) — Topical aloe helps minor burns; oral aloe has modest glucose and IBS signals but a laxative/safety caveat. · Pycnogenol (Pine Bark) (C) — A pine-bark polyphenol with broad small-trial signals for circulation, blood pressure, and skin — much of it single-source. · Sea Buckthorn (C) — An omega-7-rich berry oil with genuine dry-eye and skin-barrier signals. · DMAE (D) — A choline-adjacent compound for focus and skin with weak, mixed evidence.

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Sources

This entry lists no references of its own — it is assembled from the entries it links to, whose sources are on their pages.

Last revised . A grade is this entry's reading of the evidence, not medical advice.