Supplements for migraine

4 compounds relevant to migraine, ranked by overall evidence grade.

Overall grade: Grade B
Last revised: Jul 10, 2026; 4
graded outcomes: 0
references listed

Assembled by the app from other entries in this library. It adds no evidence of its own — follow the links to the entries it draws on.

3 at grade B · 1 at grade C — 4 graded rows

What is known

Each outcome with its grade (how strong the evidence is, A to D), the size of the effect where the entry records one, and how often studies agree.

Outcome	Grade	Effect size	Agreement
MagnesiumA cofactor in 300+ reactions that a large fraction of adults under-consume — real, modest benefits for sleep, blood pressure, and migraine.	Evidence grade B	Unclear	mixed
ButterburSolid evidence for migraine prevention and allergic rhinitis — but only PA-free products are safe.	Evidence grade B	Unclear	mixed
Riboflavin (B2)A B-vitamin with one standout use: high-dose riboflavin genuinely prevents migraines.	Evidence grade B	Unclear	mixed
FeverfewA migraine-prevention herb with modest, inconsistent trial support.	Evidence grade C	Unclear	mixed

MagnesiumEvidence grade B
A cofactor in 300+ reactions that a large fraction of adults under-consume — real, modest benefits for sleep, blood pressure, and migraine.
Unclearmixed
ButterburEvidence grade B
Solid evidence for migraine prevention and allergic rhinitis — but only PA-free products are safe.
Unclearmixed
Riboflavin (B2)Evidence grade B
A B-vitamin with one standout use: high-dose riboflavin genuinely prevents migraines.
Unclearmixed
FeverfewEvidence grade C
A migraine-prevention herb with modest, inconsistent trial support.
Unclearmixed

What is uncertain

Read off the same rows as above. Nothing here is added that the entry does not itself record.

Thin evidence: Feverfew (grade C).
Studies disagree: Magnesium (mixed agreement); Butterbur (mixed agreement); Riboflavin (B2) (mixed agreement).

The evidence in words

The shortlist

Every compound in the knowledge base tagged to migraine, ordered by how strong its overall evidence is. Start at the top; the grade is the honest filter.

Worth considering first

Magnesium (B) — A cofactor in 300+ reactions that a large fraction of adults under-consume — real, modest benefits for sleep, blood pressure, and migraine. · Butterbur (B) — Solid evidence for migraine prevention and allergic rhinitis — but only PA-free products are safe. · Riboflavin (B2) (B) — A B-vitamin with one standout use: high-dose riboflavin genuinely prevents migraines.

Lower-evidence options

Feverfew (C) — A migraine-prevention herb with modest, inconsistent trial support.

Goes with

MagnesiumGrade BEvidence grade B
ButterburGrade BEvidence grade B
Riboflavin (B2)Grade BEvidence grade B
FeverfewGrade CEvidence grade C

Entries that share this one's tags or conditions.

Butterbur for MigraineEvidence grade B — PA-free onlyEvidence grade B
Feverfew for MigraineEvidence grade C — ProphylacticEvidence grade C
Magnesium for MigraineEvidence grade B — Prophylactic; 400–600 mgEvidence grade B
Riboflavin (B2) for MigraineEvidence grade B — Prophylactic, high-doseEvidence grade B

Sources

This entry lists no references of its own — it is assembled from the entries it links to, whose sources are on their pages.

Last revised Jul 10, 2026. A grade is this entry's reading of the evidence, not medical advice.