Riboflavin (B2) for Migraine

Evidence grade B — Prophylactic, high-dose

Assembled by the app from other entries in this library. It adds no evidence of its own — follow the links to the entries it draws on.

1 at grade B — 1 graded row

What is known

Each outcome with its grade (how strong the evidence is, A to D), the size of the effect where the entry records one, and how often studies agree.

Outcome	Grade	Effect size	Agreement
MigraineProphylactic, high-dose	Evidence grade B	Unclear	mixed

Read off the same rows as above. Nothing here is added that the entry does not itself record.

For migraine, Riboflavin (B2) earns evidence grade B (unclear effect, mixed consistency) — there is real evidence here. Prophylactic, high-dose

As FAD/FMN it supports mitochondrial energy production; the migraine benefit is thought to reflect improved brain mitochondrial function.

400 mg/day for migraine prophylaxis (give it 2–3 months); requirement is milligrams from food.

Very safe; harmless bright-yellow urine at high doses.

A cheap, safe, guideline-backed migraine preventive at 400 mg/day. Give it a couple of months.

As the entry records it, from the studies it summarises. Not a recommendation for you — doses that suit a trial population may not suit you.

Entries that share this one's tags or conditions.

Magnesium for MigraineEvidence grade B — Prophylactic; 400–600 mgEvidence grade B
Riboflavin (B2) for DeficiencyEvidence grade A — DefinitionalEvidence grade A
Riboflavin (B2) for Migraine frequencyEvidence grade B — 400 mg/dayEvidence grade B
Butterbur for MigraineEvidence grade B — PA-free onlyEvidence grade B

This entry lists no references of its own — it is assembled from the entries it links to, whose sources are on their pages.

Last revised Jul 10, 2026. A grade is this entry's reading of the evidence, not medical advice.