Evidence brief · Supplement
Butterbur for Migraine
Evidence grade B — PA-free only
- Overall grade
- Grade B
- Last revised
- 1
- graded outcome
- 0
- references listed
Assembled by the app from other entries in this library. It adds no evidence of its own — follow the links to the entries it draws on.
1 at grade B — 1 graded row
What is known
Each outcome with its grade (how strong the evidence is, A to D), the size of the effect where the entry records one, and how often studies agree.
- MigraineEvidence grade B
PA-free only
Unclearmixed
What is uncertain
Read off the same rows as above. Nothing here is added that the entry does not itself record.
- Studies disagree: Migraine (mixed agreement).
The evidence in words
The verdict
For migraine, Butterbur earns evidence grade B (unclear effect, mixed consistency) — there is real evidence here. PA-free only
How it might work
Petasin compounds have anti-inflammatory and smooth-muscle effects relevant to migraine and allergy.
How to use it
Only certified PA-free standardized extract (e.g., 50–75 mg twice daily for migraine).
Safety & cautions
PA-containing products are hepatotoxic and carcinogenic — use only PA-free certified extracts.
Bottom line
Genuinely effective for migraine and hay fever, but ONLY as a certified PA-free product — otherwise it can damage the liver.
How it is used
As the entry records it, from the studies it summarises. Not a recommendation for you — doses that suit a trial population may not suit you.
- Standard
- PA-free extract, 50–75 mg twice daily.
Goes with
- ButterburRead the full Butterbur monographEvidence grade B
Related reading
Entries that share this one's tags or conditions.
- Butterbur for Allergic rhinitisEvidence grade B — Antihistamine-comparable in trialsEvidence grade B
- Butterbur for Migraine preventionEvidence grade B — PA-free extractEvidence grade B
- Butterbur: dosage and how to take itPA-free extract, 50–75 mg twice daily.Evidence grade B
- Butterbur: side effects, safety & interactionsPA-containing products are hepatotoxic and carcinogenic — use only PA-free certified extracts.Evidence grade B
Sources
This entry lists no references of its own — it is assembled from the entries it links to, whose sources are on their pages.
Last revised . A grade is this entry's reading of the evidence, not medical advice.