Riboflavin (B2) for Deficiency

Evidence grade A — Definitional

Assembled by the app from other entries in this library. It adds no evidence of its own — follow the links to the entries it draws on.

1 at grade A — 1 graded row

What is known

Each outcome with its grade (how strong the evidence is, A to D), the size of the effect where the entry records one, and how often studies agree.

Outcome	Grade	Effect size	Agreement
DeficiencyDefinitional	Evidence grade A	Large	high

For deficiency, Riboflavin (B2) earns evidence grade A (large effect, high consistency) — there is real evidence here. Definitional

As FAD/FMN it supports mitochondrial energy production; the migraine benefit is thought to reflect improved brain mitochondrial function.

400 mg/day for migraine prophylaxis (give it 2–3 months); requirement is milligrams from food.

Very safe; harmless bright-yellow urine at high doses.

A cheap, safe, guideline-backed migraine preventive at 400 mg/day. Give it a couple of months.

As the entry records it, from the studies it summarises. Not a recommendation for you — doses that suit a trial population may not suit you.

Entries that share this one's tags or conditions.

Riboflavin (B2) for MigraineEvidence grade B — Prophylactic, high-doseEvidence grade B
Magnesium for MigraineEvidence grade B — Prophylactic; 400–600 mgEvidence grade B
Riboflavin (B2) for Migraine frequencyEvidence grade B — 400 mg/dayEvidence grade B
Vitamin B12 for Cognitive declineEvidence grade C — Corrects deficiency-linked decline onlyEvidence grade C

This entry lists no references of its own — it is assembled from the entries it links to, whose sources are on their pages.

Last revised Jul 10, 2026. A grade is this entry's reading of the evidence, not medical advice.