Compound or practice · Supplement
Feverfew
A migraine-prevention herb with modest, inconsistent trial support.
- Overall grade
- Grade C
- Last revised
- 1
- graded outcome
- 0
- references listed
A structured monograph in Prometheus's bundled library. Its grades are the monograph's own reading of the evidence, not a peer-reviewed review.
2 at grade C — 2 graded rows
What is known
Each outcome with its grade (how strong the evidence is, A to D), the size of the effect where the entry records one, and how often studies agree.
- Migraine frequencyEvidence grade C
Inconsistent
Smallmixed
Conditions
How the entry reads its effect on diagnosed conditions: the direction first, then the grade. Never a substitute for the person who treats you.
- Migraine May improveEvidence grade CProphylacticGrade C
What is uncertain
Read off the same rows as above. Nothing here is added that the entry does not itself record.
- Thin evidence: Migraine frequency (grade C).
Interactions
Documented pairings with supplements and medicines. A medicine on this list is a conversation for whoever prescribes it.
MagnesiumWorks together
Common migraine-prevention stack.
The evidence in words
What it is
Feverfew (Tanacetum parthenium) is standardized to parthenolide and used for migraine prophylaxis.
How it works
Anti-inflammatory and serotonin-modulating actions relevant to migraine pathophysiology.
What the evidence shows
Some trials show reduced migraine frequency, others are null; standardization varies. It is a reasonable second-line botanical, often paired with magnesium and riboflavin.
How to use it
Standardized extract (parthenolide) daily for prevention; give it 1–2 months.
Safety & interactions
Generally tolerated; mouth ulcers with raw leaf; mild antiplatelet effect; rebound headaches on abrupt stop. Magnesium — Common migraine-prevention stack.
Bottom line
A modest migraine-prevention option, best stacked with magnesium and riboflavin. Standardized product, give it a couple of months.
How it is used
As the entry records it, from the studies it summarises. Not a recommendation for you — doses that suit a trial population may not suit you.
- Standard
- Standardized parthenolide daily, 1–2 months.
Goes with
- MagnesiumCommon migraine-prevention stack.Evidence grade B
Related reading
Entries that share this one's tags or conditions.
- Feverfew for MigraineEvidence grade C — ProphylacticEvidence grade C
- Feverfew for Migraine frequencyEvidence grade C — InconsistentEvidence grade C
- Feverfew: dosage and how to take itStandardized parthenolide daily, 1–2 months.Evidence grade C
- Feverfew: side effects, safety & interactionsGenerally tolerated; mouth ulcers with raw leaf; mild antiplatelet effect; rebound headaches on abrupt stop.Evidence grade C
Sources
This entry lists no references of its own.
Last revised . A grade is this entry's reading of the evidence, not medical advice.