Supplements for energy & fatigue

7 compounds relevant to energy & fatigue, ranked by overall evidence grade.

Overall grade: Grade A
Last revised: Jul 10, 2026; 7
graded outcomes: 0
references listed

Assembled by the app from other entries in this library. It adds no evidence of its own — follow the links to the entries it draws on.

1 at grade A · 1 at grade B · 5 at grade C — 7 graded rows

What is known

Each outcome with its grade (how strong the evidence is, A to D), the size of the effect where the entry records one, and how often studies agree.

Outcome	Grade	Effect size	Agreement
IronOnly supplement it against a ferritin number — transformative in deficiency, pro-oxidant and constipating in excess.	Evidence grade A	Unclear	mixed
Rhodiola RoseaA stimulating adaptogen with the best fatigue evidence among the herbal 'stress' supplements — daytime energy without ashwagandha's flatness.	Evidence grade B	Unclear	mixed
Panax GinsengA classic tonic with scattered small wins for fatigue, cognition, and erectile function — rarely dramatic, watch drug interactions.	Evidence grade C	Unclear	mixed
L-OrnithineA urea-cycle amino acid with small data for exercise fatigue and stress-related sleep.	Evidence grade C	Unclear	mixed
SulbutiamineA fat-soluble thiamine derivative used for fatigue — modest, real-ish, with tolerance concerns.	Evidence grade C	Unclear	mixed
Eleuthero (Siberian Ginseng)A gentle adaptogen for fatigue and stress — not a true ginseng, and modestly evidenced.	Evidence grade C	Unclear	mixed
ShilajitA mineral-rich Himalayan resin with early testosterone and fatigue signals — promising, small-trial, and quality-dependent.	Evidence grade C	Unclear	mixed

IronEvidence grade A
Only supplement it against a ferritin number — transformative in deficiency, pro-oxidant and constipating in excess.
Unclearmixed
Rhodiola RoseaEvidence grade B
A stimulating adaptogen with the best fatigue evidence among the herbal 'stress' supplements — daytime energy without ashwagandha's flatness.
Unclearmixed
Panax GinsengEvidence grade C
A classic tonic with scattered small wins for fatigue, cognition, and erectile function — rarely dramatic, watch drug interactions.
Unclearmixed
L-OrnithineEvidence grade C
A urea-cycle amino acid with small data for exercise fatigue and stress-related sleep.
Unclearmixed
SulbutiamineEvidence grade C
A fat-soluble thiamine derivative used for fatigue — modest, real-ish, with tolerance concerns.
Unclearmixed
Eleuthero (Siberian Ginseng)Evidence grade C
A gentle adaptogen for fatigue and stress — not a true ginseng, and modestly evidenced.
Unclearmixed
ShilajitEvidence grade C
A mineral-rich Himalayan resin with early testosterone and fatigue signals — promising, small-trial, and quality-dependent.
Unclearmixed

What is uncertain

Read off the same rows as above. Nothing here is added that the entry does not itself record.

Thin evidence: Panax Ginseng (grade C); L-Ornithine (grade C); Sulbutiamine (grade C); Eleuthero (Siberian Ginseng) (grade C); Shilajit (grade C).
Studies disagree: Iron (mixed agreement); Rhodiola Rosea (mixed agreement).

The evidence in words

The shortlist

Every compound in the knowledge base tagged to energy & fatigue, ordered by how strong its overall evidence is. Start at the top; the grade is the honest filter.

Worth considering first

Iron (A) — Only supplement it against a ferritin number — transformative in deficiency, pro-oxidant and constipating in excess. · Rhodiola Rosea (B) — A stimulating adaptogen with the best fatigue evidence among the herbal 'stress' supplements — daytime energy without ashwagandha's flatness.

Lower-evidence options

Panax Ginseng (C) — A classic tonic with scattered small wins for fatigue, cognition, and erectile function — rarely dramatic, watch drug interactions. · L-Ornithine (C) — A urea-cycle amino acid with small data for exercise fatigue and stress-related sleep. · Sulbutiamine (C) — A fat-soluble thiamine derivative used for fatigue — modest, real-ish, with tolerance concerns. · Eleuthero (Siberian Ginseng) (C) — A gentle adaptogen for fatigue and stress — not a true ginseng, and modestly evidenced. · Shilajit (C) — A mineral-rich Himalayan resin with early testosterone and fatigue signals — promising, small-trial, and quality-dependent.

Goes with

IronGrade AEvidence grade A
Rhodiola RoseaGrade BEvidence grade B
Panax GinsengGrade CEvidence grade C
L-OrnithineGrade CEvidence grade C
SulbutiamineGrade CEvidence grade C
Eleuthero (Siberian Ginseng)Grade CEvidence grade C
ShilajitGrade CEvidence grade C

Entries that share this one's tags or conditions.

Panax Ginseng for FatigueEvidence grade C — Small, heterogeneousEvidence grade C
Shilajit for FatigueEvidence grade C — EarlyEvidence grade C
Eleuthero (Siberian Ginseng) for Fatigue / stress toleranceEvidence grade C — Limited qualityEvidence grade C
Eleuthero (Siberian Ginseng): side effects, safety & interactionsGenerally safe; mild stimulation and possible additive effects with diabetes and blood-pressure drugs.Evidence grade C

Sources

This entry lists no references of its own — it is assembled from the entries it links to, whose sources are on their pages.

Last revised Jul 10, 2026. A grade is this entry's reading of the evidence, not medical advice.