Compound or practice · Supplement
Sulbutiamine
A fat-soluble thiamine derivative used for fatigue — modest, real-ish, with tolerance concerns.
- Overall grade
- Grade C
- Last revised
- 1
- graded outcome
- 0
- references listed
A structured monograph in Prometheus's bundled library. Its grades are the monograph's own reading of the evidence, not a peer-reviewed review.
1 at grade C — 1 graded row
What is known
Each outcome with its grade (how strong the evidence is, A to D), the size of the effect where the entry records one, and how often studies agree.
- Fatigue / astheniaEvidence grade C
Short-term
Smallmixed
What is uncertain
Read off the same rows as above. Nothing here is added that the entry does not itself record.
- Thin evidence: Fatigue / asthenia (grade C).
The evidence in words
What it is
Sulbutiamine is a synthetic, brain-penetrant form of vitamin B1 marketed for fatigue and motivation.
How it works
It raises brain thiamine and modulates cholinergic, glutamatergic, and dopaminergic signaling.
What the evidence shows
Some evidence for reducing asthenia (chronic fatigue) and possibly diabetic neuropathy; cognitive/mood claims in healthy people are weaker. Tolerance and mild dependence are reported with regular use.
Safety & interactions
Generally tolerated; cycle to avoid tolerance.
Bottom line
A reasonable short-term fatigue aid derived from B1; cycle it, and don't expect a lasting nootropic effect.
Related reading
Entries that share this one's tags or conditions.
- Sulbutiamine for Fatigue / astheniaEvidence grade C — Short-termEvidence grade C
- Sulbutiamine: side effects, safety & interactionsGenerally tolerated; cycle to avoid tolerance.Evidence grade C
- AniracetamA fat-soluble racetam with an anxiety-and-mood reputation and mostly preclinical human backing.Evidence grade D
- CentrophenoxineAn old cholinergic anti-aging compound with dated cognitive-decline data.Evidence grade D
Sources
This entry lists no references of its own.
Last revised . A grade is this entry's reading of the evidence, not medical advice.