Evidence brief · Supplement
Sulbutiamine for Fatigue / asthenia
Evidence grade C — Short-term
- Overall grade
- Grade C
- Last revised
- 1
- graded outcome
- 0
- references listed
Assembled by the app from other entries in this library. It adds no evidence of its own — follow the links to the entries it draws on.
1 at grade C — 1 graded row
What is known
Each outcome with its grade (how strong the evidence is, A to D), the size of the effect where the entry records one, and how often studies agree.
- Fatigue / astheniaEvidence grade C
Short-term
Smallmixed
What is uncertain
Read off the same rows as above. Nothing here is added that the entry does not itself record.
- Thin evidence: Fatigue / asthenia (grade C).
The evidence in words
The verdict
For fatigue / asthenia, Sulbutiamine earns evidence grade C (small effect, mixed consistency) — the evidence is limited or mixed. Short-term
How it might work
It raises brain thiamine and modulates cholinergic, glutamatergic, and dopaminergic signaling.
How to use it
Safety & cautions
Generally tolerated; cycle to avoid tolerance.
Bottom line
A reasonable short-term fatigue aid derived from B1; cycle it, and don't expect a lasting nootropic effect.
Goes with
- SulbutiamineRead the full Sulbutiamine monographEvidence grade C
Related reading
Entries that share this one's tags or conditions.
- Panax Ginseng for FatigueEvidence grade C — Small, heterogeneousEvidence grade C
- Shilajit for FatigueEvidence grade C — EarlyEvidence grade C
- Sulbutiamine: side effects, safety & interactionsGenerally tolerated; cycle to avoid tolerance.Evidence grade C
- AniracetamA fat-soluble racetam with an anxiety-and-mood reputation and mostly preclinical human backing.Evidence grade D
Sources
This entry lists no references of its own — it is assembled from the entries it links to, whose sources are on their pages.
Last revised . A grade is this entry's reading of the evidence, not medical advice.